Telomeric repeat-binding factor 2

TERF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H6P, 1VF9, 1VFC, 1W0U, 1XG1, 3BU8, 3BUA, 3K6G, 3SJM, 4M7C, 4RQI
Identifiers
Aliases	TERF2, TRBF2, TRF2, telomeric repeat binding factor 2
External IDs	OMIM: 602027 MGI: 1195972 HomoloGene: 4133 GeneCards: TERF2
Gene location (Human)
Chr.	Chromosome 16 (human)
End	69,408,571 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	107,096,547 bp
RNA expression pattern
	Top expressed in
	Brodmann area 46; ; sural nerve; ; ganglionic eminence; ; postcentral gyrus; ; orbitofrontal cortex; ; prefrontal cortex; ; gastrocnemius muscle; ; superior frontal gyrus; ; lymph node; ; frontal pole;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; retinal pigment epithelium; ; ciliary body; ; secondary oocyte; ; thymus; ; ganglionic eminence; ; islet of Langerhans; ; iris; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; double-stranded telomeric DNA binding; protein homodimerization activity; telomeric DNA binding; telomerase activity; protein C-terminus binding; protein binding; G-rich strand telomeric DNA binding; enzyme binding; protein-containing complex binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nuclear telomere cap complex; chromosome; telomere; Mre11 complex; nucleus; nucleoplasm; nuclear body; shelterin complex; axon cytoplasm;
Biological process	negative regulation of telomere single strand break repair; regulation of telomere maintenance; negative regulation of telomere maintenance via semi-conservative replication; negative regulation of gene expression; negative regulation of beta-galactosidase activity; protein localization to chromosome, telomeric region; cellular senescence; negative regulation of telomere capping; positive regulation of gene expression; positive regulation of nitric-oxide synthase activity; negative regulation of t-circle formation; cell cycle; telomeric loop formation; negative regulation of cellular senescence; telomere capping; negative regulation of telomere maintenance via telomere lengthening; negative regulation of exonuclease activity; telomeric D-loop disassembly; negative regulation of telomeric D-loop disassembly; negative regulation of telomere maintenance via recombination; telomere maintenance; RNA-dependent DNA biosynthetic process; negative regulation of telomere maintenance; regulation of telomere maintenance via telomerase; negative regulation of telomere maintenance via telomerase; protection from non-homologous end joining at telomere; regulation of transcription by RNA polymerase II; anterograde axonal transport of messenger ribonucleoprotein complex;
	Sources:Amigo / QuickGO
Orthologs
	7014
	21750
	ENSG00000132604
	ENSMUSG00000031921
	Q15554
	O35144
	NM_005652
	NM_001083118; NM_001286200; NM_009353
	NP_005643
NP_001076587; NP_001273129; NP_033379; NP_001357994; NP_001357995;
	NP_001357996
	Wikidata
View/Edit Human	View/Edit Mouse

Telomeric repeat-binding factor 2 is a protein that is present at telomeres throughout the cell cycle. It is also known as TERF2, TRF2, and TRBF2, and is encoded in humans by the TERF2 gene. It is a component of the shelterin nucleoprotein complex and a second negative regulator of telomere length, playing a key role in the protective activity of telomeres. It was first reported in 1997 in the lab of Titia de Lange, where a DNA sequence similar, but not identical, to TERF1 was discovered, with respect to the Myb-domain. De Lange isolated the new Myb-containing protein sequence and called it TERF2.

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