TBX21

TBX21
Identifiers
Aliases	TBX21, T-PET, T-bet, TBET, TBLYM, T-box 21, T-box transcription factor 21, IMD88
External IDs	OMIM: 604895 MGI: 1888984 HomoloGene: 8353 GeneCards: TBX21
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,746,122 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,006,157 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; lymph node; ; bone marrow cells; ; tibialis anterior muscle; ; upper lobe of left lung; ; appendix; ; monocyte; ; right lung; ; right lobe of liver;
	Top expressed in
	female urethra; ; blood; ; olfactory bulb; ; spleen; ; spinal ganglia; ; extraocular muscle; ; thymus; ; subcutaneous adipose tissue; ; sternocleidomastoid muscle; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	neuronal cell body; nucleus;
Biological process	multicellular organism development; positive regulation of transcription, DNA-templated; cellular response to organic substance; positive regulation of isotype switching to IgG isotypes; response to virus; T cell differentiation; regulation of transcription, DNA-templated; lymphocyte migration; transcription, DNA-templated; regulation of immune response; negative regulation of transcription by RNA polymerase II; negative regulation of interleukin-2 production; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of T cell differentiation; negative regulation of transcription, DNA-templated; negative regulation of T-helper 17 cell differentiation; negative regulation of T-helper 17 cell lineage commitment; negative regulation of T-helper 2 cell cytokine production; positive regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	30009
	57765
	ENSG00000073861
	ENSMUSG00000001444
	Q9UL17
	Q9JKD8
	NM_013351
	NM_019507
	NP_037483
	NP_062380
	Wikidata
View/Edit Human	View/Edit Mouse

T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells) is a protein that in humans is encoded by the TBX21 gene. Though being for long thought of only as a master regulator of type 1 immune response, T-bet has recently been shown to be implicated in development of various immune cell subsets and maintenance of mucosal homeostasis.

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