TAR DNA-binding protein 43

TARDBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WF0, 2CQG, 4BS2, 4IUF, 4Y0F, 2N4P, 2N2C, 4Y00, 2N4G, 2N4H, 2N3X
Identifiers
Aliases	TARDBP, ALS10, TDP-43, TAR DNA binding protein
External IDs	OMIM: 605078 MGI: 2387629 HomoloGene: 7221 GeneCards: TARDBP
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,030,528 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,711,476 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; tibia; ; rectum; ; left lobe of thyroid gland; ; tibial nerve; ; visceral pleura; ; anterior pituitary; ; right lobe of thyroid gland; ; islet of Langerhans;
	Top expressed in
	primitive streak; ; spermatocyte; ; otic placode; ; abdominal wall; ; saccule; ; ureter; ; ganglionic eminence; ; dermis; ; yolk sac; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; mRNA 3'-UTR binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; identical protein binding; RNA binding; nucleic acid binding; double-stranded DNA binding; single-stranded RNA binding; sequence-specific double-stranded DNA binding;
Cellular component	cytoplasm; nuclear speck; nucleoplasm; interchromatin granule; perichromatin fibrils; nucleus; ribonucleoprotein complex; cytoplasmic stress granule;
Biological process	negative regulation of protein phosphorylation; regulation of transcription, DNA-templated; mRNA processing; negative regulation of gene expression; response to endoplasmic reticulum stress; transcription, DNA-templated; regulation of cell cycle; negative regulation by host of viral transcription; RNA splicing; nuclear inner membrane organization; 3'-UTR-mediated mRNA stabilization; positive regulation of transcription by RNA polymerase II; positive regulation of insulin secretion; transcription by RNA polymerase II; regulation of apoptotic process; positive regulation of protein import into nucleus; regulation of protein stability; regulation of circadian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	23435
	230908
	ENSG00000120948
	ENSMUSG00000041459
	Q13148
	Q921F2
	NM_007375
NM_001003898; NM_001003899; NM_001008545; NM_001008546; NM_145556;
	NM_001305425
	NP_031401; NP_031401.1
NP_001003898; NP_001003899; NP_001008545; NP_001008546; NP_001292354;
	NP_663531
	Wikidata
View/Edit Human	View/Edit Mouse

TAR DNA-binding protein 43 (TDP-43, transactive response DNA binding protein 43 kDa) is a protein that in humans is encoded by the TARDBP gene.

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