Syncytin-2

ERVFRD-1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y4M
Identifiers
Aliases	ERVFRD-1, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, endogenous retrovirus group FRD member 1, endogenous retrovirus group FRD member 1, envelope
External IDs	OMIM: 610524 MGI: 3045308 HomoloGene: 86779 GeneCards: ERVFRD-1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	11,111,725 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	69,531,748 bp
RNA expression pattern
	Top expressed in
	placenta; ; retinal pigment epithelium; ; gallbladder; ; fundus; ; left adrenal gland; ; smooth muscle tissue; ; urinary bladder; ; gastric mucosa; ; rectum; ; small intestine;
	Top expressed in
	placenta; ; ovary; ; jejunum;
	More reference expression data
	n/a
Orthologs
	405754
	239167
	ENSG00000244476
	ENSMUSG00000047977
	P60508
	Q8BI41
	NM_207582
	NM_173420
	NP_997465
	NP_775596
	Wikidata
View/Edit Human	View/Edit Mouse

Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by the ERVFRD-1 gene. This protein plays a key role in the implantation of human embryos in the womb.

This gene is conserved among all primates, with an estimated age of 45 million years. The receptor for this fusogenic env protein is MFSD2. The mouse syncytins are not true orthologues.

The virus, along with some very similar insertions, belong to a group under the Gammaretrovirus-like class I ERVs. Similar ERVs are found in artiodactyls, a result of an independent integration event. A proposed nomenclature suggests putting all such "class I" elements in a genus-level taxon separate from Gammaretrovirus.

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