Sup35p
Sup35p is the Saccharomyces cerevisiae (a yeast) eukaryotic translation release factor. More specifically, it is the yeast eukaryotic release factor 3 (eRF3), which forms the translation termination complex with eRF1 (Sup45p in yeast). This complex recognizes and catalyzes the release of the nascent polypeptide chain when the ribosome encounters a stop codon. While eRF1 recognizes stop codons, eRF3 facilitates the release of the polypeptide chain through GTP hydrolysis.
| Eukaryotic peptide chain release factor GTP-binding subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Sus35 | ||||||
| Entrez | 851752 | ||||||
| HomoloGene | 68226 | ||||||
| RefSeq (mRNA) | NM_001180479.3 | ||||||
| RefSeq (Prot) | NP_010457.3 | ||||||
| UniProt | P05453 | ||||||
| Other data | |||||||
| Chromosome | IV: 0.81 - 0.81 Mb | ||||||
| |||||||
Partial loss of function results in nonsense suppression, in which stop codons are ignored and proteins are abnormally synthesized with carboxyl terminal extensions. Complete loss of function is fatal.
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