Sulfonylurea receptor

ATP-binding cassette, subfamily C (CFTR/MRP), member 9
ATP-binding cassette, subfamily C (CFTR/MRP), member 9
Identifiers
Symbol	ABCC9
Alt. symbols	SUR2A, SUR2B
NCBI gene	10060
HGNC	60
OMIM	601439
RefSeq	NM_005691
UniProt	O60706
Other data
Locus	Chr. 12 p12.1
Structures
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Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

ATP-binding cassette, subfamily C (CFTR/MRP), member 8
ATP-binding cassette, subfamily C (CFTR/MRP), member 8
Identifiers
Symbol	ABCC8
Alt. symbols	SUR1
NCBI gene	6833
HGNC	59
OMIM	600509
RefSeq	NM_000352
UniProt	Q09428
Other data
Locus	Chr. 11 p15.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

In molecular biology, the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels K_ir6.x (6.1 and 6.2). The association of four K_ir6.x and four SUR subunits form an ion conducting channel commonly referred to as the K_ATP channel.

Three forms of the sulfonylurea receptor are known, SUR1 encoded by the ABCC8 gene, and SUR2A and SUR2B, which are splice variants arising from a single ABCC9 gene.

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