Sucrase-isomaltase

Sucrase-isomaltase is a bifunctional glucosidase (sugar-digesting enzyme) located on the brush border of the small intestine, encoded by the human gene SI. It is a dual-function enzyme with two GH31 domains, one serving as the isomaltase, the other as a sucrose alpha-glucosidase. It has preferential expression in the apical membranes of enterocytes. The enzyme’s purpose is to digest dietary carbohydrates such as starch, sucrose and isomaltose. By further processing the broken-down products, energy in the form of ATP can be generated.

SI
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSI, sucrase-isomaltase
External IDsOMIM: 609845 MGI: 1917233 HomoloGene: 37424 GeneCards: SI
Orthologs
SpeciesHumanMouse
Entrez

6476

69983

Ensembl

ENSG00000090402

ENSMUSG00000027790

UniProt

P14410

F8VQM5

RefSeq (mRNA)

NM_001041

NM_001081137

RefSeq (protein)

NP_001032

NP_001074606

Location (UCSC)Chr 3: 164.98 – 165.08 MbChr 3: 72.8 – 72.88 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse
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