Sucrase-isomaltase

SI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LPO, 3LPP
Identifiers
Aliases	SI, sucrase-isomaltase
External IDs	OMIM: 609845 MGI: 1917233 HomoloGene: 37424 GeneCards: SI
Gene location (Human)
Chr.	Chromosome 3 (human)
End	165,078,496 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	72,875,196 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; sperm; ; rectum; ; appendix; ; bone marrow cells; ; smooth muscle tissue; ; testicle; ; pancreatic epithelial cell; ; pancreatic ductal cell;
	Top expressed in
	duodenum; ; jejunum; ; ileum; ; colon; ; crypt of lieberkuhn of small intestine; ; intestinal epithelium; ; intestinal villus; ; thymus; ; esophagus; ; pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	sucrose alpha-glucosidase activity; oligo-1,6-glucosidase activity; hydrolase activity, hydrolyzing O-glycosyl compounds; catalytic activity; alpha-1,4-glucosidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; carbohydrate binding;
Cellular component	integral component of membrane; plasma membrane; Golgi apparatus; apical plasma membrane; extracellular exosome; membrane; brush border;
Biological process	polysaccharide digestion; metabolism; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6476
	69983
	ENSG00000090402
	ENSMUSG00000027790
	P14410
	F8VQM5
	NM_001041
	NM_001081137
	NP_001032
	NP_001074606
	Wikidata
View/Edit Human	View/Edit Mouse

Sucrase-isomaltase is a bifunctional glucosidase (sugar-digesting enzyme) located on the brush border of the small intestine, encoded by the human gene SI. It is a dual-function enzyme with two GH31 domains, one serving as the isomaltase, the other as a sucrose alpha-glucosidase. It has preferential expression in the apical membranes of enterocytes. The enzyme’s purpose is to digest dietary carbohydrates such as starch, sucrose and isomaltose. By further processing the broken-down products, energy in the form of ATP can be generated.

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