Subtilisin
Subtilisin is a protease (a protein-digesting enzyme) initially obtained from Bacillus subtilis.
| Peptidase S8, subtilisin-related | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Peptidase_S8 | ||||||||
| Pfam | PF00082 | ||||||||
| InterPro | IPR015500 | ||||||||
| PROSITE | PDOC00125 | ||||||||
| CATH | 1cse | ||||||||
| SCOP2 | 1cse / SCOPe / SUPFAM | ||||||||
| CDD | cd07477 | ||||||||
| |||||||||
| Subtilisin BPN' | |||||||
|---|---|---|---|---|---|---|---|
Crystal structure of subtilisin S8 domain. | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | apr | ||||||
| CAS number | 9014-01-1 | ||||||
| Entrez | 5712479 | ||||||
| PDB | 1st2 More structures | ||||||
| UniProt | P00782 | ||||||
| Other data | |||||||
| EC number | 3.4.21.62 | ||||||
| |||||||
| GO:0004252 | |||||||
Subtilisins belong to subtilases, a group of serine proteases that – like all serine proteases – initiate the nucleophilic attack on the peptide (amide) bond through a serine residue at the active site. Subtilisins typically have molecular weights 27kDa. They can be obtained from certain types of soil bacteria, for example, Bacillus amyloliquefaciens from which they are secreted in large amounts.
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