Streptolysin

Streptolysin S
Streptolysin S
Identifiers
Organism	Streptococcus pyogenes serotype M4 (strain MGAS10750)
Symbol	sagA
UniProt	Q1J7I0
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

Streptolysin O
Streptolysin O
Identifiers
Organism	Streptococcus pyogenes serotype M1
Symbol	slo
UniProt	P0C0I3
Structures
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Structures	Swiss-model
Domains	InterPro

Streptolysins are two hemolytic exotoxins from Streptococcus pyogenes. Types include streptolysin O (SLO; slo), which is oxygen-labile, and streptolysin S (SLS; sagA), which is oxygen-stable.

SLO is part of the thiol-activated cytolysin family. It is hemolytically active only in a reversibly reduced state. It is antigenic, so its antibody antistreptolysin O can be detected in an antistreptolysin O titre.

SLS is stable in the presence of oxygen. It is not antigenic due to its small size. It is sometimes considered a bacteriocin due to similarities in the synthesis pathway.

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