Stem cell factor

KITLG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EXZ, 1SCF, 2E9W
Identifiers
Aliases	KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF
External IDs	OMIM: 184745 MGI: 96974 HomoloGene: 692 GeneCards: KITLG
Gene location (Human)
Chr.	Chromosome 12 (human)
End	88,580,851 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	99,936,278 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; cardia; ; lower lobe of lung; ; pylorus; ; middle temporal gyrus; ; parietal pleura; ; endothelial cell; ; seminal vesicula; ; renal medulla; ; vena cava;
	Top expressed in
	habenula; ; left lung lobe; ; medial geniculate nucleus; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; dermis; ; cerebellar vermis; ; right lung; ; iris; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	stem cell factor receptor binding; protein binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; cytokine activity;
Cellular component	integral component of membrane; membrane; extracellular region; cytoskeleton; cell projection; filopodium; lamellipodium; cytoplasm; plasma membrane; extracellular space;
Biological process	male gonad development; MAPK cascade; cell adhesion; embryonic hemopoiesis; cell population proliferation; signal transduction; phosphatidylinositol phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; positive regulation of cell population proliferation; ovarian follicle development; neural crest cell migration; positive regulation of leukocyte migration; positive regulation of myeloid leukocyte differentiation; negative regulation of mast cell apoptotic process; ectopic germ cell programmed cell death; negative regulation of apoptotic process; positive regulation of MAP kinase activity; positive regulation of melanocyte differentiation; positive regulation of Ras protein signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of mast cell proliferation; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of hematopoietic stem cell proliferation; positive regulation of hematopoietic progenitor cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4254
	17311
	ENSG00000049130
	ENSMUSG00000019966
	P21583
	P20826
	NM_003994; NM_000899
	NM_013598; NM_001347156
	NP_000890; NP_003985
	NP_001334085; NP_038626
	Wikidata
View/Edit Human	View/Edit Mouse

Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.

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