Proto-oncogene tyrosine-protein kinase Src

SRC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47, 1O48, 1O49, 1O4A, 1O4B, 1O4C, 1O4D, 1O4E, 1O4F, 1O4G, 1O4H, 1O4I, 1O4J, 1O4K, 1O4L, 1O4M, 1O4N, 1O4O, 1O4P, 1O4Q, 1O4R, 1SHD, 1Y57, 1YI6, 1YOJ, 1YOL, 1YOM, 2BDF, 2H8H, 3VRO, 3ZMP, 3ZMQ, 4F59, 4F5A, 4F5B, 4HXJ, 4K11, 4MXO, 4MXX, 4MXY, 4MXZ
Identifiers
Aliases	SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6
External IDs	OMIM: 190090 MGI: 98397 HomoloGene: 21120 GeneCards: SRC
EC number	2.7.10.2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	37,406,050 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	157,471,862 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; gallbladder; ; rectum; ; body of pancreas; ; transverse colon; ; ganglionic eminence; ; gastric mucosa; ; ascending aorta; ; canal of the cervix; ; left adrenal gland;
	Top expressed in
	external carotid artery; ; superior frontal gyrus; ; internal carotid artery; ; molar; ; aortic valve; ; ascending aorta; ; jejunum; ; medial geniculate nucleus; ; ganglionic eminence; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; protein domain specific binding; protein-containing complex binding; SH2 domain binding; kinase activity; signaling receptor binding; estrogen receptor binding; ATP binding; protein kinase activity; insulin receptor binding; non-membrane spanning protein tyrosine kinase activity; kinase binding; heme binding; enzyme binding; transferase activity; ephrin receptor binding; scaffold protein binding; integrin binding; protein binding; protein kinase binding; cell adhesion molecule binding; protein kinase C binding; hormone receptor binding; nucleotide binding; growth factor receptor binding; phosphoprotein binding; protein tyrosine kinase activity; protein C-terminus binding; ubiquitin protein ligase binding; cadherin binding; connexin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; ruffle membrane; mitochondrion; perinuclear region of cytoplasm; caveola; neuron projection; cytoskeleton; nucleus; lysosome; extracellular exosome; late endosome; plasma membrane; actin filament; postsynaptic density; mitochondrial inner membrane; podosome; nucleoplasm; glutamatergic synapse; postsynaptic specialization, intracellular component;
Biological process	response to mineralocorticoid; negative regulation of telomere maintenance via telomerase; response to interleukin-1; positive regulation of MAP kinase activity; positive regulation of canonical Wnt signaling pathway; negative regulation of telomerase activity; cellular response to progesterone stimulus; regulation of intracellular estrogen receptor signaling pathway; stress fiber assembly; positive regulation of protein serine/threonine kinase activity; platelet activation; positive regulation of smooth muscle cell migration; protein phosphorylation; regulation of vascular permeability; vascular endothelial growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; regulation of podosome assembly; cell cycle; substrate adhesion-dependent cell spreading; osteoclast development; cell population proliferation; transforming growth factor beta receptor signaling pathway; cellular response to hypoxia; cellular response to transforming growth factor beta stimulus; negative regulation of protein homooligomerization; positive regulation of protein kinase B signaling; positive regulation of lamellipodium morphogenesis; epidermal growth factor receptor signaling pathway; branching involved in mammary gland duct morphogenesis; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway; response to mechanical stimulus; response to virus; positive regulation of epithelial cell migration; signal complex assembly; stimulatory C-type lectin receptor signaling pathway; positive regulation of platelet-derived growth factor receptor signaling pathway; oogenesis; positive regulation of transcription, DNA-templated; regulation of epithelial cell migration; response to nutrient levels; positive regulation of DNA biosynthetic process; cellular response to insulin stimulus; protein autophosphorylation; viral process; negative regulation of focal adhesion assembly; response to acidic pH; response to fatty acid; regulation of cell projection assembly; phosphorylation; immune system process; negative regulation of mitochondrial depolarization; positive regulation of integrin activation; negative regulation of apoptotic process; cellular response to platelet-derived growth factor stimulus; positive regulation of podosome assembly; positive regulation of glucose metabolic process; transcytosis; cellular response to fluid shear stress; response to electrical stimulus; positive regulation of protein transport; uterus development; protein destabilization; regulation of cell-cell adhesion; peptidyl-tyrosine autophosphorylation; integrin-mediated signaling pathway; positive regulation of insulin receptor signaling pathway; progesterone receptor signaling pathway; negative regulation of transcription, DNA-templated; adherens junction organization; negative regulation of anoikis; response to hydrogen peroxide; leukocyte migration; activation of protein kinase B activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; intracellular signal transduction; regulation of early endosome to late endosome transport; ephrin receptor signaling pathway; T cell costimulation; positive regulation of intracellular signal transduction; regulation of caveolin-mediated endocytosis; regulation of cell cycle; positive regulation of phosphatidylinositol 3-kinase activity; cellular response to reactive oxygen species; cellular response to peptide hormone stimulus; positive regulation of gene expression; cellular response to fatty acid; regulation of cell population proliferation; angiotensin-activated signaling pathway involved in heart process; peptidyl-serine phosphorylation; positive regulation of protein autophosphorylation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of apoptotic process; forebrain development; regulation of protein binding; cellular response to lipopolysaccharide; regulation of bone resorption; cell migration; signal transduction; positive regulation of cell adhesion; cell adhesion; positive regulation of protein processing; innate immune response; positive regulation of peptidyl-tyrosine phosphorylation; neurotrophin TRK receptor signaling pathway; positive regulation of small GTPase mediated signal transduction; bone resorption; central nervous system development; positive regulation of protein localization to nucleus; platelet-derived growth factor receptor signaling pathway; ERBB2 signaling pathway; intracellular estrogen receptor signaling pathway; axon guidance; macroautophagy; peptidyl-tyrosine phosphorylation; entry of bacterium into host cell; cell-cell adhesion; primary ovarian follicle growth; positive regulation of ovarian follicle development; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; cell differentiation; phosphatidylinositol phosphate biosynthetic process; regulation of postsynaptic neurotransmitter receptor activity; positive regulation of non-membrane spanning protein tyrosine kinase activity; G protein-coupled receptor signaling pathway; cellular response to hydrogen peroxide; positive regulation of platelet-derived growth factor receptor-beta signaling pathway; odontogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6714
	20779
	ENSG00000197122
	ENSMUSG00000027646
	P12931
	P05480
	NM_005417; NM_198291
	NM_001025395; NM_009271
	NP_005408; NP_938033
	NP_001020566; NP_033297
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. It belongs to a family of Src family kinases and is similar to the v-Src (viral Src) gene of Rous sarcoma virus. It includes an SH2 domain, an SH3 domain and a tyrosine kinase domain. Two transcript variants encoding the same protein have been found for this gene.

c-Src phosphorylates specific tyrosine residues in other tyrosine kinases. It plays a role in the regulation of embryonic development and cell growth. An elevated level of activity of c-Src is suggested to be linked to cancer progression by promoting other signals. Mutations in c-Src could be involved in the malignant progression of colon cancer. c-Src should not be confused with CSK (C-terminal Src kinase), an enzyme that phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity.

c-Src was originally discovered by American scientists J. Michael Bishop and Harold E. Varmus, for which they were awarded the 1989 Nobel Prize in Physiology or Medicine.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.