Sotalol

Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. Evidence does not support a decreased risk of death with long term use. It is taken by mouth or given by injection into a vein.

Sotalol
Clinical data
Trade namesBetapace, Sorine, Sotylize, others
AHFS/Drugs.comMonograph
MedlinePlusa693010
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
Drug classBeta blocker
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability90–100%
MetabolismNot metabolized
Elimination half-life12 hours
ExcretionKidney
Mammary gland (In lactating individuals)
Identifiers
  • (RS)-N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H20N2O3S
Molar mass272.36 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • O=S(=O)(Nc1ccc(cc1)C(O)CNC(C)C)C
  • InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 Y
  • Key:ZBMZVLHSJCTVON-UHFFFAOYSA-N Y
  (verify)

Common side effects include a slow heart rate, chest pain, low blood pressure, feeling tired, dizziness, shortness of breath, problems seeing, vomiting, and swelling. Other serious side effects may include QT prolongation, heart failure, or bronchospasm. Sotalol is a non-selective β-adrenergic receptor blocker which has both class II and class III antiarrhythmic properties.

Sotalol was first described in 1964 and came into medical use in 1974. It is available as a generic medication. In 2020, it was the 296th most commonly prescribed medication in the United States, with more than 1 million prescriptions.

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