Somatostatin receptor

Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.

somatostatin receptor 1
Identifiers
SymbolSSTR1
NCBI gene6751
HGNC11330
OMIM182451
RefSeqNM_001049
UniProtP30872
Other data
LocusChr. 14 q13
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StructuresSwiss-model
DomainsInterPro
somatostatin receptor 2
Identifiers
SymbolSSTR2
NCBI gene6752
HGNC11331
OMIM182452
RefSeqNM_001050
UniProtP30874
Other data
LocusChr. 17 q24
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StructuresSwiss-model
DomainsInterPro
somatostatin receptor 3
Identifiers
SymbolSSTR3
NCBI gene6753
HGNC11332
OMIM182453
RefSeqNM_001051
UniProtP32745
Other data
LocusChr. 22 q13.1
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DomainsInterPro
somatostatin receptor 4
Identifiers
SymbolSSTR4
NCBI gene6754
HGNC11333
OMIM182454
RefSeqNM_001052
UniProtP31391
Other data
LocusChr. 20 p11.2
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StructuresSwiss-model
DomainsInterPro
somatostatin receptor 5
Identifiers
SymbolSSTR5
NCBI gene6755
HGNC11334
OMIM182455
RefSeqNM_001053
UniProtP35346
Other data
LocusChr. 16 p13.3
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StructuresSwiss-model
DomainsInterPro

There are five known somatostatin receptors:

All are G protein-coupled seven transmembrane receptors.

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