Sodium zirconium cyclosilicate

Sodium zirconium cyclosilicate, sold under the brand name Lokelma, is a medication used to treat high blood potassium. Onset of effects occurs in one to six hours. It is taken by mouth.

Sodium zirconium cyclosilicate
Crystal structure of ZS-9. Blue spheres  =  oxygen atoms, red spheres  =  zirconium atoms, green spheres  =  silicon atoms.
Clinical data
Trade namesLokelma
Other namesZS-9
AHFS/Drugs.comMonograph
MedlinePlusa618035
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityNot absorbed
ExcretionFeces
Identifiers
  • Silicic acid, sodium zirconium(4+) salt (3:2:1), hydrate
CAS Number
DrugBank
UNII
KEGG
Chemical and physical data
Formula(2Na·H2O·3H4SiO4·H4ZrO6)n

Common side effects include swelling and low blood potassium. Use is likely safe in pregnancy and breastfeeding. It works by binding potassium ions in the gastrointestinal tract which is then lost in the stool.

Sodium zirconium cyclosilicate was approved for medical use in the European Union and in the United States in 2018. It was developed by AstraZeneca.

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