Sevoflurane

Sevoflurane
Clinical data
Trade names	Sojourn, Ultane, Sevorane, others
AHFS/Drugs.com	Consumer Drug Information
Pregnancy; category	AU: B2;
Routes of; administration	Inhaled
ATC code	N01AB08 (WHO) QN01AB08 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); CA: ℞-only; UK: POM (Prescription only); EU: Rx-only;
Pharmacokinetic data
Metabolism	Liver by CYP2E1
Metabolites	Hexafluoroisopropanol
Elimination half-life	15–23 hours
Excretion	Kidney
Identifiers
	IUPAC name 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane;
CAS Number	28523-86-6 ;
PubChem CID	5206;
IUPHAR/BPS	7296;
DrugBank	DB01236 ;
ChemSpider	5017 ;
UNII	38LVP0K73A;
KEGG	D00547 ;
ChEBI	CHEBI:9130 ;
ChEMBL	ChEMBL1200694 ;
CompTox Dashboard (EPA)	DTXSID8046614 ;
ECHA InfoCard	100.171.146
Chemical and physical data
Formula	C4H3F7O
Molar mass	200.056 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.53 g/cm3
Boiling point	58.5 °C (137.3 °F)
	SMILES FC(F)(F)C(OCF)C(F)(F)F;
	InChI InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2 ; Key:DFEYYRMXOJXZRJ-UHFFFAOYSA-N ;
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Sevoflurane, sold under the brand name Sevorane, among others, is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used as an inhalational anaesthetic for induction and maintenance of general anesthesia. After desflurane, it is the volatile anesthetic with the fastest onset. While its offset may be faster than agents other than desflurane in a few circumstances, its offset is more often similar to that of the much older agent isoflurane. While sevoflurane is only half as soluble as isoflurane in blood, the tissue blood partition coefficients of isoflurane and sevoflurane are quite similar. For example, in the muscle group: isoflurane 2.62 vs. sevoflurane 2.57. In the fat group: isoflurane 52 vs. sevoflurane 50. As a result, the longer the case, the more similar will be the emergence times for sevoflurane and isoflurane.

It is on the World Health Organization's List of Essential Medicines.

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