Selenophosphate synthetase 1

SEPHS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FD5, 3FD6
Identifiers
Aliases	SEPHS1, SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDs	OMIM: 600902 MGI: 1923580 HomoloGene: 56558 GeneCards: SEPHS1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	13,348,298 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	4,910,557 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; islet of Langerhans; ; oocyte; ; secondary oocyte; ; rectum; ; internal globus pallidus; ; right lobe of liver; ; left lobe of thyroid gland; ; endothelial cell; ; body of pancreas;
	Top expressed in
	maxillary prominence; ; condyle; ; ganglionic eminence; ; abdominal wall; ; primitive streak; ; internal carotid artery; ; external carotid artery; ; cumulus cell; ; medial ganglionic eminence; ; endocardial cushion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; selenide, water dikinase activity; GTP binding; protein binding; ATP binding; protein homodimerization activity; identical protein binding; protein heterodimerization activity; kinase activity;
Cellular component	cytoplasm; plasma membrane; nuclear membrane; membrane; nucleus;
Biological process	phosphorylation; selenocysteine biosynthetic process; selenium compound metabolic process; tRNA seleno-modification;
	Sources:Amigo / QuickGO
Orthologs
	22929
	109079
	ENSG00000086475
	ENSMUSG00000026662
	P49903; Q5T5U7
	Q8BH69
	NM_001195602; NM_001195604; NM_012247; NM_001375769; NM_001375770
	NM_175400
	NP_001182531; NP_001182533; NP_036379; NP_001362698
	NP_780609; NP_001349636; NP_001349637; NP_001349638; NP_001349639
	Wikidata
View/Edit Human	View/Edit Mouse

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.

This protein functions as an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.

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