SV2A

SV2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V11
Identifiers
Aliases	SV2A, SV2, synaptic vesicle glycoprotein 2A
External IDs	OMIM: 185860 MGI: 1927139 HomoloGene: 32237 GeneCards: SV2A
Gene location (Human)
Chr.	Chromosome 1 (human)
End	149,917,844 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,102,837 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; superior frontal gyrus; ; middle temporal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; cerebellar vermis; ; pons; ; superior vestibular nucleus; ; ventral tegmental area;
	Top expressed in
	lateral geniculate nucleus; ; lateral hypothalamus; ; mammillary body; ; ventral tegmental area; ; pontine nuclei; ; superior colliculus; ; cerebellar cortex; ; dorsal tegmental nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter activity; transporter activity; protein kinase binding; signaling receptor activity;
Cellular component	membrane; synaptic vesicle; cell-cell junction; neuromuscular junction; plasma membrane; synapse; presynaptic active zone; cell junction; endoplasmic reticulum; cytoplasmic vesicle; integral component of membrane; integral component of synaptic vesicle membrane; synaptic vesicle membrane; neuron projection; dendrite; neuronal cell body; glutamatergic synapse; GABA-ergic synapse;
Biological process	cellular calcium ion homeostasis; transmembrane transport; neurotransmitter transport; regulation of gamma-aminobutyric acid secretion; chemical synaptic transmission; signal transduction; synaptic vesicle priming;
	Sources:Amigo / QuickGO
Orthologs
	9900
	64051
	ENSG00000159164
	ENSMUSG00000038486
	Q7L0J3
	Q9JIS5
	NM_014849; NM_001278719; NM_001328674; NM_001328675
	NM_022030
	NP_001265648; NP_001315603; NP_001315604; NP_055664
	NP_071313
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene. The protein is targeted by the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.