Somatostatin receptor 2

SSTR2
Identifiers
Aliases	SSTR2, Somatostatin receptor 2
External IDs	OMIM: 182452 MGI: 98328 HomoloGene: 37427 GeneCards: SSTR2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	73,176,633 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	113,516,854 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar cortex; ; cerebellar hemisphere; ; islet of Langerhans; ; cerebellar vermis; ; superior frontal gyrus; ; prefrontal cortex; ; postcentral gyrus; ; dorsolateral prefrontal cortex; ; cingulate gyrus;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; habenula; ; cingulate gyrus; ; primary motor cortex; ; ganglionic eminence; ; piriform cortex; ; visual cortex; ; interventricular septum; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; G protein-coupled receptor activity; neuropeptide binding; PDZ domain binding; somatostatin receptor activity; peptide binding;
Cellular component	integral component of plasma membrane; cytoplasm; integral component of membrane; membrane; neuron projection; plasma membrane; cytosol;
Biological process	cerebellum development; regulation of muscle contraction; neuropeptide signaling pathway; peristalsis; cellular response to glucocorticoid stimulus; response to starvation; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of cell population proliferation; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; spermatogenesis; cellular response to estradiol stimulus; signal transduction; forebrain development; somatostatin signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6752
	20606
	ENSG00000180616
	ENSMUSG00000047904
	P30874
	P30875
	NM_001050
	NM_001042606; NM_009217
	NP_001041
	NP_001036071; NP_033243
	Wikidata
View/Edit Human	View/Edit Mouse

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.

The SSTR2 gene is located on chromosome 17 on the long arm in position 25.1 in humans. It is also found in most other vertebrates.

The somatostatin receptor 2 (SSTR2), which belongs to the G-protein coupled receptor family, is a protein which is most highly expressed in the pancreas (both alpha- and beta-cells), but also in other tissues such as the cerebrum and kidney and in lower amount in the jejunum, colon and liver. In the pancreas, after binding to somatostatin, it inhibits the secretion of peptide hormones from pancreatic islets. During development, it stimulates neuronal migration and axon outgrowth.

The somatostatin receptor 2 is expressed in most tumors. Patients with neuroendocrine tumors that over-express the somatostatin receptor 2 have an improved prognosis. The over expression of SSTR2 in tumors can be exploited to selectively deliver radio-peptides to tumors to either detect or destroy them. Somatostatin receptor 2 also has the ability to stimulate apoptosis in many cells including cancer cells. The somatostatin receptor 2 is also being looked at as a possible target in cancer treatment for its ability to inhibit tumor growth.

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