SRGAP2

SRGAP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RTT, 4RUG, 2DL8
Identifiers
Aliases	SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase activating protein 2
External IDs	OMIM: 606524 MGI: 109605 HomoloGene: 52683 GeneCards: SRGAP2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,464,436 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,455,090 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; sural nerve; ; ganglionic eminence; ; skin of abdomen; ; monocyte; ; corpus callosum; ; right lung; ; upper lobe of left lung; ; Achilles tendon; ; right adrenal gland;
	Top expressed in
	cerebellar cortex; ; cerebellar vermis; ; superior frontal gyrus; ; lip; ; ganglionic eminence; ; ankle; ; medial ganglionic eminence; ; esophagus; ; body of femur; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein binding; GTPase activator activity; identical protein binding;
Cellular component	cytoplasm; cytosol; postsynaptic membrane; cell projection; membrane; postsynaptic density; dendritic spine; synapse; cell junction; dendritic spine head; phagocytic vesicle; cytoplasmic vesicle; nucleus; lamellipodium; plasma membrane; nucleoplasm;
Biological process	lamellipodium assembly involved in ameboidal cell migration; negative regulation of neuron migration; neuron projection morphogenesis; actin filament severing; filopodium assembly; negative regulation of cell death; nervous system development; dendritic spine development; substrate adhesion-dependent cell spreading; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration; cell population proliferation; regulation of small GTPase mediated signal transduction; signal transduction; positive regulation of GTPase activity; negative regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	23380
	14270
	ENSG00000266028
	ENSMUSG00000026425
	O75044
	Q91Z67
NM_001042758; NM_001170637; NM_001300952; NM_015326; NM_001377444;
	NM_001377445; NM_001377446; NM_001377447
	NM_001081011; NM_019520
NP_001164108; NP_001287881; NP_056141; NP_001364373; NP_001364374;
	NP_001364375; NP_001364376
	NP_001074480
	Wikidata
View/Edit Human	View/Edit Mouse

SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene. It is involved in neuronal migration and differentiation and plays a critical role in synaptic development, brain mass and number of cortical neurons. Downregulation of srGAP2 inhibits cell–cell repulsion and enhances cell–cell contact duration.

SRGAP2 dimerizes through its F-BAR domain. SRGAP2C, a shortened version found in early hominins and humans that only has the F-BAR domain, antagonizes its action. It slows maturation of some neurons and increases neuronal spine density.

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