Sterol regulatory element-binding protein 1

SREBF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AM9
Identifiers
Aliases	SREBF1, SREBP-1c, SREBP1, bHLHd1, SREBP1a, sterol regulatory element binding transcription factor 1
External IDs	OMIM: 184756 MGI: 107606 HomoloGene: 3079 GeneCards: SREBF1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	17,837,011 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,113,407 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; right adrenal gland; ; right lobe of liver; ; left uterine tube; ; minor salivary gland; ; tibial nerve; ; anterior pituitary; ; gallbladder; ; skin of abdomen; ; canal of the cervix;
	Top expressed in
	white adipose tissue; ; lip; ; urinary bladder; ; exocrine gland; ; hepatobiliary system; ; liver; ; skeletal muscle tissue; ; olfactory bulb; ; islet of Langerhans; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity; sterol response element binding; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; protein binding; protein kinase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; nuclear receptor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific; protein-containing complex binding; enzyme activator activity;
Cellular component	cytoplasm; integral component of membrane; cytosol; Golgi apparatus; nuclear envelope; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; Golgi membrane; nucleoplasm; endoplasmic reticulum; ER to Golgi transport vesicle membrane; cytoplasmic vesicle; nucleus; protein-containing complex;
Biological process	positive regulation of histone deacetylation; insulin receptor signaling pathway; positive regulation of triglyceride biosynthetic process; steroid metabolic process; negative regulation of insulin secretion; response to fatty acid; lipid biosynthetic process; response to glucagon; regulation of protein stability; regulation of transcription, DNA-templated; response to retinoic acid; response to organic cyclic compound; lung development; lipid metabolism; regulation of insulin secretion; regulation of transcription by RNA polymerase II; cellular response to starvation; response to progesterone; human ageing; response to peptide hormone; mRNA transcription by RNA polymerase II; cholesterol metabolic process; negative regulation of transcription by RNA polymerase II; response to glucose; transcription, DNA-templated; positive regulation of transcription, DNA-templated; response to lipid; cellular response to fatty acid; regulation of autophagy of mitochondrion; regulation of protein targeting to mitochondrion; regulation of fatty acid metabolic process; circadian rhythm; cellular response to insulin stimulus; response to food; positive regulation of cholesterol biosynthetic process; response to cAMP; regulation of heart rate by chemical signal; fat cell differentiation; intracellular receptor signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of cholesterol biosynthetic process; transcription by RNA polymerase II; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	6720
	20787
	ENSG00000072310
	ENSMUSG00000020538
	P36956
	Q9WTN3
	NM_001005291; NM_004176; NM_001321096
	NM_011480; NM_001313979; NM_001358314; NM_001358315
	NP_001005291; NP_001308025; NP_004167
	NP_001300908; NP_035610; NP_001345243; NP_001345244
	Wikidata
View/Edit Human	View/Edit Mouse

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene.

This gene is located within the Smith–Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. The isoforms are SREBP-1a and SREBP-1c (the latter also called ADD-1). SREBP-1a is expressed in the intestine and spleen, whereas SREBP-1c is mainly expressed in liver, muscle, and fat (among other tissues).

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