Mothers against decapentaplegic homolog 5

SMAD5
Identifiers
Aliases	SMAD5, DWFC, JV5-1, MADH5, SMAD family member 5
External IDs	OMIM: 603110 MGI: 1328787 HomoloGene: 4313 GeneCards: SMAD5
Gene location (Human)
Chr.	Chromosome 5 (human)
End	136,188,747 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	56,890,190 bp
RNA expression pattern
	Top expressed in
	caput epididymis; ; lactiferous duct; ; corpus epididymis; ; nipple; ; germinal epithelium; ; superficial temporal artery; ; Achilles tendon; ; endothelial cell; ; urethra; ; secondary oocyte;
	Top expressed in
	maxillary prominence; ; Paneth cell; ; ureter; ; medial ganglionic eminence; ; hair follicle; ; left lung lobe; ; renal corpuscle; ; condyle; ; molar; ; endocardial cushion;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; metal ion binding; protein binding; ubiquitin protein ligase binding; DEAD/H-box RNA helicase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	SMAD protein complex; transcription regulator complex; intracellular anatomical structure; nucleoplasm; nucleus; cytoplasm; cytosol; protein-containing complex;
Biological process	germ cell development; ureteric bud development; cardiac muscle contraction; regulation of transcription, DNA-templated; SMAD protein signal transduction; embryonic pattern specification; ossification; cellular response to organic cyclic compound; cellular response to BMP stimulus; BMP signaling pathway; transcription, DNA-templated; positive regulation of transcription, DNA-templated; Mullerian duct regression; protein phosphorylation; cartilage development; positive regulation of osteoblast differentiation; erythrocyte differentiation; bone development; transforming growth factor beta receptor signaling pathway; signal transduction; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transcription by RNA polymerase II; osteoblast fate commitment; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4090
	17129
	ENSG00000113658
	ENSMUSG00000021540
	Q99717
	P97454
	NM_005903; NM_001001419; NM_001001420
	NM_001164041; NM_001164042; NM_008541
	NP_001001419; NP_001001420; NP_005894
	NP_001157513; NP_001157514; NP_032567
	Wikidata
View/Edit Human	View/Edit Mouse

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community. It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

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