Mothers against decapentaplegic homolog 3

SMAD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG
Identifiers
Aliases	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
External IDs	OMIM: 603109 MGI: 1201674 HomoloGene: 55937 GeneCards: SMAD3
Gene location (Human)
Chr.	Chromosome 15 (human)
End	67,195,173 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	63,665,276 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; synovial joint; ; mucosa of urinary bladder; ; vagina; ; right lobe of thyroid gland; ; islet of Langerhans; ; left lobe of thyroid gland; ; thymus; ; Achilles tendon; ; tibialis anterior muscle;
	Top expressed in
	temporal muscle; ; triceps brachii muscle; ; molar; ; ankle; ; sternocleidomastoid muscle; ; internal carotid artery; ; external carotid artery; ; fossa; ; digastric muscle; ; secondary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphatase binding; DNA-binding transcription factor activity; R-SMAD binding; co-SMAD binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; enzyme binding; transforming growth factor beta receptor binding; protein homodimerization activity; collagen binding; zinc ion binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; protein binding; double-stranded DNA binding; protein kinase binding; sequence-specific DNA binding; DNA binding; bHLH transcription factor binding; ubiquitin binding; identical protein binding; protein heterodimerization activity; chromatin DNA binding; ubiquitin protein ligase binding; beta-catenin binding; RNA polymerase II general transcription initiation factor activity; DEAD/H-box RNA helicase binding; mineralocorticoid receptor binding; glucocorticoid receptor binding; primary miRNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; SMAD binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription coregulator activity;
Cellular component	cytoplasm; nucleus; heteromeric SMAD protein complex; SMAD protein complex; transcription regulator complex; receptor complex; plasma membrane; intracellular anatomical structure; nucleoplasm; nuclear inner membrane; cytosol; protein-containing complex;
Biological process	somitogenesis; skeletal system development; ureteric bud development; endoderm development; regulation of transforming growth factor beta2 production; embryonic pattern specification; regulation of transcription by RNA polymerase II; negative regulation of osteoblast differentiation; heart looping; positive regulation of chondrocyte differentiation; positive regulation of alkaline phosphatase activity; positive regulation of interleukin-1 beta production; pericardium development; regulation of binding; negative regulation of wound healing; activation of cysteine-type endopeptidase activity involved in apoptotic process; transforming growth factor beta receptor signaling pathway; negative regulation of inflammatory response; positive regulation of positive chemotaxis; negative regulation of cell population proliferation; negative regulation of fat cell differentiation; cell-cell junction organization; regulation of transcription, DNA-templated; extrinsic apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; signal transduction involved in regulation of gene expression; in utero embryonic development; negative regulation of transforming growth factor beta receptor signaling pathway; nodal signaling pathway; positive regulation of transcription, DNA-templated; negative regulation of cell growth; regulation of immune response; positive regulation of transforming growth factor beta3 production; T cell activation; activin receptor signaling pathway; regulation of striated muscle tissue development; embryonic foregut morphogenesis; positive regulation of bone mineralization; wound healing; negative regulation of apoptotic process; positive regulation of extracellular matrix assembly; negative regulation of transcription by RNA polymerase II; positive regulation of epithelial to mesenchymal transition; mitigation of host defenses by virus; thyroid gland development; developmental growth; lens fiber cell differentiation; gastrulation; immune response; osteoblast differentiation; primary miRNA processing; negative regulation of osteoblast proliferation; osteoblast development; embryonic cranial skeleton morphogenesis; transdifferentiation; paraxial mesoderm morphogenesis; response to hypoxia; positive regulation of cell migration; mesoderm formation; regulation of transforming growth factor beta receptor signaling pathway; positive regulation of gene expression; immune system development; positive regulation of focal adhesion assembly; liver development; regulation of epithelial cell proliferation; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase II; negative regulation of mitotic cell cycle; negative regulation of cytosolic calcium ion concentration; canonical Wnt signaling pathway; protein stabilization; transcription, DNA-templated; negative regulation of protein catabolic process; protein deubiquitination; positive regulation of nitric oxide biosynthetic process; negative regulation of lung blood pressure; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of cardiac muscle hypertrophy in response to stress; cellular response to transforming growth factor beta stimulus; cellular response to cytokine stimulus; positive regulation of protein import into nucleus; positive regulation of DNA-binding transcription factor activity; SMAD protein signal transduction; positive regulation of canonical Wnt signaling pathway; SMAD protein complex assembly; adrenal gland development;
	Sources:Amigo / QuickGO
Orthologs
	4088
	17127
	ENSG00000166949
	ENSMUSG00000032402
	P84022
	Q8BUN5
	NM_001145102; NM_001145103; NM_001145104; NM_005902
	NM_016769
	NP_001138574; NP_001138575; NP_001138576; NP_005893
	NP_058049
	Wikidata
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Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

SMAD3 is a member of the SMAD family of proteins. It acts as a mediator of the signals initiated by the transforming growth factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.

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