Mothers against decapentaplegic homolog 1

SMAD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A
Identifiers
Aliases	SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1
External IDs	OMIM: 601595 MGI: 109452 HomoloGene: 21196 GeneCards: SMAD1
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	80,126,147 bp
RNA expression pattern
	n/a
	Top expressed in
	Paneth cell; ; ureter; ; conjunctival fornix; ; fossa; ; medullary collecting duct; ; internal carotid artery; ; lacrimal gland; ; hair follicle; ; condyle; ; seminal vesicula;
	More reference expression data
Gene ontology
Molecular function	DNA binding; co-SMAD binding; protein homodimerization activity; I-SMAD binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; protein binding; identical protein binding; protein heterodimerization activity; protein kinase binding; sequence-specific DNA binding; DEAD/H-box RNA helicase binding; primary miRNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; integral component of membrane; SMAD protein complex; cytosol; transcription regulator complex; intracellular anatomical structure; nucleoplasm; nuclear inner membrane; nucleus; protein-containing complex;
Biological process	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; SMAD protein complex assembly; ureteric bud development; regulation of transcription, DNA-templated; SMAD protein signal transduction; embryonic pattern specification; regulation of transcription by RNA polymerase II; cellular response to organic cyclic compound; hindbrain development; cellular response to BMP stimulus; cardiac muscle cell proliferation; BMP signaling pathway; transcription, DNA-templated; MAPK cascade; protein phosphorylation; gamete generation; cartilage development; positive regulation of gene expression; positive regulation of osteoblast differentiation; positive regulation of cartilage development; primary miRNA processing; mesodermal cell fate commitment; inflammatory response; bone development; transforming growth factor beta receptor signaling pathway; midbrain development; signal transduction; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; osteoblast fate commitment; homeostatic process; transcription by RNA polymerase II; positive regulation of pri-miRNA transcription by RNA polymerase II; protein deubiquitination; positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4086
	17125
	ENSG00000170365
	ENSMUSG00000031681
	Q15797
	P70340
	NM_001003688; NM_005900
	NM_008539
NP_001003688; NP_005891; NP_001341740; NP_001341741; NP_001341742;
	NP_001341743; NP_001341745; NP_001341746
	NP_032565
	Wikidata
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Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.

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