SIRPB1

SIRPB1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2D9C, 2JJU,%%s2JJV
Identifiers
Aliases	SIRPB1, CD172b, SIRP-BETA-1, signal regulatory protein beta 1
External IDs	OMIM: 603889 MGI: 3779828 HomoloGene: 82993 GeneCards: SIRPB1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,620,061 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	15,640,125 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; right lung; ; spleen; ; bone marrow; ; bone marrow cells; ; appendix; ; gallbladder; ; lymph node; ; upper lobe of left lung;
	Top expressed in
	spermatid; ; secondary oocyte; ; bone marrow; ; spleen; ; lung; ; jejunum; ; liver; ; uterus; ; spermatocyte; ; ovary;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; secretory granule membrane; cell surface;
Biological process	cell surface receptor signaling pathway; innate immune response; signal transduction; neutrophil degranulation; positive regulation of cell-cell adhesion; positive regulation of phagocytosis; positive regulation of T cell activation;
	Sources:Amigo / QuickGO
Orthologs
	10326
	668101
	ENSG00000101307
	ENSMUSG00000095028
	O00241; Q5TFQ8
	n/a
	NM_001083910; NM_001135844; NM_006065; NM_001329157; NM_001330639
	NM_001173460
NP_001077379; NP_001129316; NP_001316086; NP_001317568; NP_006056;
	NP_001129316.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.

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