Sirtuin 1

SIRT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4I5I, 4IF6, 4IG9, 4KXQ, 4ZZH, 4ZZI, 4ZZJ, 5BTR
Identifiers
Aliases	SIRT1, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1
External IDs	OMIM: 604479 MGI: 2135607 HomoloGene: 56556 GeneCards: SIRT1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	67,918,390 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	63,217,483 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; gastric mucosa; ; monocyte; ; lower lobe of lung; ; gallbladder; ; gastrocnemius muscle; ; germinal epithelium; ; right lung; ; islet of Langerhans;
	Top expressed in
	spermatocyte; ; primitive streak; ; superior cervical ganglion; ; hair follicle; ; ciliary body; ; cumulus cell; ; medial ganglionic eminence; ; abdominal wall; ; retinal pigment epithelium; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; protein domain specific binding; core promoter sequence-specific DNA binding; protein C-terminus binding; keratin filament binding; transcription factor binding; metal ion binding; HLH domain binding; enzyme binding; protein deacetylase activity; histone binding; protein binding; NAD-dependent histone deacetylase activity; NAD-dependent protein deacetylase activity; histone deacetylase activity; p53 binding; mitogen-activated protein kinase binding; deacetylase activity; bHLH transcription factor binding; NAD+ binding; identical protein binding; NAD+ ADP-ribosyltransferase activity; hydrolase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear envelope; rDNA heterochromatin; chromatin silencing complex; mitochondrion; nucleus; ESC/E(Z) complex; nucleolus; chromatin; nucleoplasm; PML body; nuclear inner membrane; cytosol;
Biological process	cellular triglyceride homeostasis; positive regulation of MHC class II biosynthetic process; DNA synthesis involved in DNA repair; positive regulation of protein phosphorylation; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; rhythmic process; single strand break repair; muscle organ development; histone H3-K9 deacetylation; negative regulation of cellular response to testosterone stimulus; regulation of peroxisome proliferator activated receptor signaling pathway; cellular response to DNA damage stimulus; regulation of bile acid biosynthetic process; DNA replication; negative regulation of TOR signaling; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of glucose metabolic process; rDNA heterochromatin assembly; negative regulation of DNA damage response, signal transduction by p53 class mediator; DNA methylation-dependent heterochromatin assembly; circadian rhythm; positive regulation of cellular senescence; spermatogenesis; intrinsic apoptotic signaling pathway in response to DNA damage; cellular response to ionizing radiation; negative regulation of helicase activity; cholesterol homeostasis; response to leptin; cellular response to hypoxia; triglyceride mobilization; negative regulation of prostaglandin biosynthetic process; proteasome-mediated ubiquitin-dependent protein catabolic process; apoptotic process; peptidyl-lysine deacetylation; negative regulation of fat cell differentiation; negative regulation of peptidyl-lysine acetylation; regulation of transcription, DNA-templated; positive regulation of adaptive immune response; stress-induced premature senescence; negative regulation of androgen receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; response to oxidative stress; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; transcription, DNA-templated; negative regulation of cAMP-dependent protein kinase activity; pyrimidine dimer repair by nucleotide-excision repair; response to insulin; histone H3-K9 modification; positive regulation of macroautophagy; positive regulation of cholesterol efflux; protein ubiquitination; negative regulation of cell growth; positive regulation of macrophage apoptotic process; rRNA processing; regulation of brown fat cell differentiation; negative regulation of phosphorylation; viral process; DNA repair; negative regulation of neuron death; positive regulation of histone H3-K9 methylation; negative regulation of histone H3-K14 acetylation; negative regulation of protein kinase B signaling; cell differentiation; ovulation from ovarian follicle; regulation of protein serine/threonine kinase activity; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; protein ADP-ribosylation; leptin-mediated signaling pathway; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; chromatin organization; negative regulation of I-kappaB kinase/NF-kappaB signaling; circadian regulation of gene expression; protein deacetylation; fatty acid homeostasis; protein destabilization; regulation of mitotic cell cycle; positive regulation of cAMP-dependent protein kinase activity; white fat cell differentiation; positive regulation of insulin receptor signaling pathway; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; peptidyl-lysine acetylation; response to hydrogen peroxide; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of histone H4-K16 acetylation; positive regulation of endothelial cell proliferation; regulation of smooth muscle cell apoptotic process; behavioral response to starvation; cellular glucose homeostasis; cellular response to starvation; cellular response to tumor necrosis factor; positive regulation of DNA repair; multicellular organism development; regulation of cell population proliferation; positive regulation of cell population proliferation; regulation of endodeoxyribonuclease activity; regulation of cellular response to heat; positive regulation of phosphatidylinositol 3-kinase signaling; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; UV-damage excision repair; histone deacetylation; positive regulation of transcription by RNA polymerase II; angiogenesis; macrophage cytokine production; regulation of lipid storage; positive regulation of adipose tissue development; macrophage differentiation; transcription by RNA polymerase II; positive regulation of smooth muscle cell differentiation; negative regulation of histone H3-K9 trimethylation; positive regulation of apoptotic process; cellular response to hydrogen peroxide; histone H3 deacetylation; negative regulation of protein acetylation; regulation of apoptotic process; cellular response to leukemia inhibitory factor; positive regulation of angiogenesis; transforming growth factor beta receptor signaling pathway; positive regulation of blood vessel endothelial cell migration; negative regulation of cellular senescence;
	Sources:Amigo / QuickGO
Orthologs
	23411
	93759
	ENSG00000096717
	ENSMUSG00000020063
	Q96EB6
	Q923E4
	NM_001142498; NM_001314049; NM_012238
	NM_001159589; NM_001159590; NM_019812
	NP_001135970; NP_001300978; NP_036370
	NP_001153061; NP_062786
	Wikidata
View/Edit Human	View/Edit Mouse

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene.

SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2. SIRT1 is an enzyme located primarily in the cell nucleus that deacetylates transcription factors that contribute to cellular regulation (reaction to stressors, longevity).

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