Sodium/glucose cotransporter 1

SLC5A1
Identifiers
Aliases	SLC5A1, D22S675, NAGT, SGLT1, solute carrier family 5 member 1
External IDs	OMIM: 182380 MGI: 107678 HomoloGene: 55456 GeneCards: SLC5A1
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	33,320,214 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; left ventricle; ; gallbladder; ; right ventricle; ; pancreatic ductal cell; ; skin of abdomen; ; islet of Langerhans; ; minor salivary gland; ; rectum;
	Top expressed in
	duodenum; ; ileum; ; intestinal villus; ; jejunum; ; left colon; ; Paneth cell; ; crypt of lieberkuhn of small intestine; ; kidney; ; seminal vesicula; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; protein binding; symporter activity; glucose:sodium symporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; cell-cell junction; plasma membrane; integral component of plasma membrane; brush border membrane; apical plasma membrane; extracellular exosome;
Biological process	glucose transmembrane transport; sodium ion transport; ion transport; carbohydrate transport; transmembrane transport; intestinal D-glucose absorption; intestinal hexose absorption; transport;
	Sources:Amigo / QuickGO
Orthologs
	6523
	20537
	n/a
	ENSMUSG00000011034
	P13866
	Q8C3K6
	NM_000343; NM_001256314
	NM_019810
	NP_000334; NP_001243243
	NP_062784
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium/glucose cotransporter 1 (SGLT1) also known as solute carrier family 5 member 1 is a protein in humans that is encoded by the SLC5A1 gene which encodes the production of the SGLT1 protein to line the absorptive cells in the small intestine and the epithelial cells of the kidney tubules of the nephron for the purpose of glucose uptake into cells. Recently, it has been seen to have functions that can be considered as promising therapeutic target to treat diabetes and obesity. Through the use of the sodium glucose cotransporter 1 protein, cells are able to obtain glucose which is further utilized to make and store energy for the cell.

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