SERBA-2

SERBA-2
Clinical data
Other names	(2S,3R,4S)-SERBA
Identifiers
	IUPAC name (3aR,4S,9bS)-4-(4-Hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol;
CAS Number	533884-10-5;
PubChem CID	9925763;
ChemSpider	8101398;
ChEMBL	ChEMBL216355;
Chemical and physical data
Formula	C18H18O3
Molar mass	282.339 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1C[C@@H]2[C@H](C1)C3=C(C=CC(=C3)O)O[C@@H]2C4=CC=C(C=C4)O;
	InChI InChI=1S/C18H18O3/c19-12-6-4-11(5-7-12)18-15-3-1-2-14(15)16-10-13(20)8-9-17(16)21-18/h4-10,14-15,18-20H,1-3H2/t14-,15+,18+/m0/s1; Key:XIESSJVMWNJCGZ-HDMKZQKVSA-N;

SERBA-2, short for selective estrogen receptor beta agonist-2, is a synthetic, nonsteroidal estrogen which acts as a selective ERβ agonist. For the ERα and ERβ, SERBA-2 has affinities (K_i) of 14.5 nM and 1.54 nM, efficacies of 85% and 100%, and EC₅₀ values of 85 nM and 3.61 nM, respectively, demonstrating 9-fold binding selectivity and 11-fold functional selectivity for the ERβ over the ERα. An enantiomer of SERBA-2, erteberel (SERBA-1), is more potent and selective in comparison and is under development for the treatment of schizophrenia.

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