Succinate dehydrogenase complex subunit C

Succinate dehydrogenase complex subunit C, also known as succinate dehydrogenase cytochrome b560 subunit, mitochondrial, is a protein that in humans is encoded by the SDHC gene. This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with pheochromocytomas and paragangliomas. Alternatively spliced transcript variants have been described.

SDHC
Identifiers
AliasesSDHC, CYB560, CYBL, PGL3, QPS1, SDH3, succinate dehydrogenase complex subunit C
External IDsOMIM: 602413 MGI: 1913302 HomoloGene: 2256 GeneCards: SDHC
Orthologs
SpeciesHumanMouse
Entrez

6391

66052

Ensembl

ENSG00000143252

ENSMUSG00000058076

UniProt

Q99643

Q9CZB0

RefSeq (mRNA)

NM_001035511
NM_001035512
NM_001035513
NM_001278172
NM_003001

NM_025321

RefSeq (protein)

NP_001030588
NP_001030589
NP_001030590
NP_001265101
NP_002992

NP_079597

Location (UCSC)Chr 1: 161.31 – 161.36 MbChr 1: 170.95 – 170.98 Mb
PubMed search
Wikidata
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