SCNN1A

SCNN1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M3O
Identifiers
Aliases	SCNN1A, BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1, sodium channel epithelial 1 alpha subunit, LIDLS3, sodium channel epithelial 1 subunit alpha
External IDs	OMIM: 600228 MGI: 101782 HomoloGene: 811 GeneCards: SCNN1A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,377,730 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,321,906 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pancreatic ductal cell; ; renal medulla; ; minor salivary gland; ; left lobe of thyroid gland; ; palpebral conjunctiva; ; right lobe of thyroid gland; ; bronchial epithelial cell; ; amniotic fluid; ; rectum;
	Top expressed in
	right lung lobe; ; esophagus; ; left lung lobe; ; pyloric antrum; ; trachea; ; lip; ; left colon; ; gastric mucosa; ; epithelium of stomach; ; mucous cell of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sodium channel activity; protein binding; ligand-gated sodium channel activity; WW domain binding;
Cellular component	integral component of membrane; cell projection; membrane; sodium channel complex; integral component of plasma membrane; cilium; ciliary membrane; extracellular exosome; plasma membrane; apical plasma membrane; cytoplasm; sperm principal piece; acrosomal vesicle; cytoplasmic vesicle; motile cilium;
Biological process	sodium ion transmembrane transport; response to stimulus; sodium ion transport; ion transport; sodium ion homeostasis; multicellular organismal water homeostasis; sensory perception of taste; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6337
	20276
	ENSG00000111319
	ENSMUSG00000030340
	P37088
	Q61180
	NM_001159576; NM_001038; NM_001159575
	NM_011324
	NP_001029; NP_001153047; NP_001153048
	NP_035454; NP_001392957; NP_001392960
	Wikidata
View/Edit Human	View/Edit Mouse

The SCNN1A gene encodes for the α subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1B, SCNN1G, and SCNN1D.

ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons. The abbreviation for the genes encoding for voltage-gated sodium channel starts with three letters: SCN. In contrast to these sodium channels, ENaC is constitutively active and is not voltage-dependent. The second N in the abbreviation (SCNN1A) represents that these are NON-voltage-gated channels.

In most vertebrates, sodium ions are the major determinant of the osmolarity of the extracellular fluid. ENaC allows transfer of sodium ions across the epithelial cell membrane in so-called "tight-epithelia" that have low permeability. The flow of sodium ions across epithelia affects osmolarity of the extracellular fluid. Thus, ENaC plays a central role in the regulation of body fluid and electrolyte homeostasis and consequently affects blood pressure.

As ENaC is strongly inhibited by amiloride, it is also referred to as an "amiloride-sensitive sodium channel".

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