Cutamesine

Cutamesine
Names
	Preferred IUPAC name 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine
Identifiers
CAS Number	165377-43-5 ; 165377-44-6 (dihydrochloride) ;
3D model (JSmol)	Interactive image;
PubChem CID	9954941;
UNII	9J7A4144BX ; B66RO93FXQ (dihydrochloride) ;
	SMILES COC1=C(OC)C=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1;
Properties
Chemical formula	C23H32N2O2
Molar mass	368.521 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic reticulum of cells in the central nervous system. These σ1 receptors play a key role in the modulation of Ca²⁺ release and apoptosis. Cutamesine's activation of the σ1 receptor is tied to a variety of physiological phenomena in the CNS, including activation of dopamine-releasing neurons and repression of the MAPK/ERK pathway.

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