S100-A1

S100A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L0P, 2LHL, 2LLS, 2LLT, 2LLU, 2LP2, 2LP3, 2LUX, 2M3W
Identifiers
Aliases	S100A1, S100, S100-alpha, S100A, S100 calcium-binding protein A1, S100 calcium binding protein A1
External IDs	OMIM: 176940 MGI: 1338917 HomoloGene: 4566 GeneCards: S100A1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,632,039 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,421,699 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; left ventricle; ; thoracic diaphragm; ; amygdala; ; nucleus accumbens; ; hypothalamus; ; putamen; ; cingulate gyrus; ; triceps brachii muscle; ; prefrontal cortex;
	Top expressed in
	utricle; ; submandibular gland; ; interventricular septum; ; myocardium of ventricle; ; right ventricle; ; brown adipose tissue; ; iris; ; extraocular muscle; ; digastric muscle; ; optic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; S100 protein binding; protein homodimerization activity; ATPase binding; calcium-dependent protein binding; metal ion binding; protein binding; identical protein binding;
Cellular component	cytoplasm; M band; I band; sarcoplasmic reticulum; Z disc; neuron projection; A band; nucleus; extracellular region; protein-containing complex;
Biological process	intracellular signal transduction; regulation of heart contraction; substantia nigra development; positive regulation of voltage-gated calcium channel activity; negative regulation of transcription by RNA polymerase II; toll-like receptor signaling pathway; positive regulation of nitric-oxide synthase activity; positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6271
	20193
	ENSG00000160678
	ENSMUSG00000044080
	P23297
	P56565
	NM_006271
	NM_011309
	NP_006262
	NP_035439
	Wikidata
View/Edit Human	View/Edit Mouse

Protein S100-A1, also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. S100A1 is highly expressed in cardiac and skeletal muscle, and localizes to Z-discs and sarcoplasmic reticulum. S100A1 has shown promise as an effective candidate for gene therapy to treat post-myocardially infarcted cardiac tissue.

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