S100B

S100B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MQ1, 1UWO, 2H61, 2M49, 2PRU, 3CZT, 3D0Y, 3D10, 3HCM, 4XYN, 5CSJ, 5CSF, 5CSN, 5CSI
Identifiers
Aliases	S100B, NEF, S100, S100-B, S100beta, S100 calcium binding protein B
External IDs	OMIM: 176990 MGI: 98217 HomoloGene: 4567 GeneCards: S100B
Gene location (Human)
Chr.	Chromosome 21 (human)
End	46,605,208 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,096,993 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; olfactory bulb; ; subthalamic nucleus; ; trigeminal ganglion; ; internal globus pallidus; ; medulla oblongata; ; superior vestibular nucleus; ; substantia nigra; ; pons; ; optic nerve;
	Top expressed in
	anterior horn of spinal cord; ; cerebellar vermis; ; stria vascularis; ; pontine nuclei; ; facial motor nucleus; ; optic nerve; ; utricle; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; S100 protein binding; protein homodimerization activity; zinc ion binding; metal ion binding; calcium-dependent protein binding; protein binding; identical protein binding; tau protein binding; signaling receptor binding; RAGE receptor binding;
Cellular component	cytoplasm; ruffle; extracellular region; neuronal cell body; perinuclear region of cytoplasm; nucleus; extracellular space;
Biological process	axonogenesis; response to glucocorticoid; memory; negative regulation of skeletal muscle cell differentiation; central nervous system development; astrocyte differentiation; positive regulation of synaptic transmission; positive regulation of cell population proliferation; regulation of cell shape; positive regulation of apoptotic process; learning or memory; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of neuronal synaptic plasticity; response to methylmercury; cell population proliferation; innate immune response; cellular response to hypoxia; long-term potentiation; positive regulation of myelination;
	Sources:Amigo / QuickGO
Orthologs
	6285
	20203
	ENSG00000160307
	ENSMUSG00000033208
	P04271
	P50114
	NM_006272
	NM_009115
	NP_006263
	NP_033141
	Wikidata
View/Edit Human	View/Edit Mouse

S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.

S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3.

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