Ricin
Ricin (/ˈraɪsɪn/ RY-sin) is a lectin (a carbohydrate-binding protein) and a highly potent toxin produced in the seeds of the castor oil plant, Ricinus communis. The median lethal dose (LD50) of ricin for mice is around 22 micrograms per kilogram of body weight via intraperitoneal injection. Oral exposure to ricin is far less toxic. An estimated lethal oral dose in humans is approximately one milligram per kilogram of body weight.
| Ricin | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | RCOM_2159910 | ||||||
| Entrez | 8287993 | ||||||
| RefSeq (mRNA) | XM_002534603.1 | ||||||
| RefSeq (Prot) | XP_002534649.1 | ||||||
| UniProt | P02879 | ||||||
| Other data | |||||||
| EC number | 3.2.2.22 | ||||||
| Chromosome | whole genome: 0 - 0.01 Mb | ||||||
| |||||||
| Ribosome-inactivating protein (Ricin A chain) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | RIP | ||||||||
| Pfam | PF00161 | ||||||||
| InterPro | IPR001574 | ||||||||
| PROSITE | PDOC00248 | ||||||||
| SCOP2 | 1paf / SCOPe / SUPFAM | ||||||||
| |||||||||
| Ricin-type beta-trefoil lectin domain (Ricin B chain) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | N/A | ||||||||
| Pfam | PF00652 | ||||||||
| Pfam clan | CL0066 | ||||||||
| PROSITE | IPR000772 | ||||||||
| SCOP2 | 1abr / SCOPe / SUPFAM | ||||||||
| CAZy | CBM13 | ||||||||
| CDD | cd00161 | ||||||||
| |||||||||
Ricin is a toxalbumin and was first described by Peter Hermann Stillmark, the founder of lectinology. Ricin is chemically similar to robin.
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