Ribonuclease T
Ribonuclease T (RNase T, exonuclease T, exo T) is a ribonuclease enzyme involved in the maturation of transfer RNA and ribosomal RNA in bacteria, as well as in DNA repair pathways. It is a member of the DnaQ family of exonucleases and non-processively acts on the 3' end of single-stranded nucleic acids. RNase T is capable of cleaving both DNA and RNA, with extreme sequence specificity discriminating against cytosine at the 3' end of the substrate.
| Ribonuclease T | |||||||||
|---|---|---|---|---|---|---|---|---|---|
A ribonuclease T dimer in complex with DNA (orange), from PDB ID 3NH1. | |||||||||
| Identifiers | |||||||||
| Symbol | rnt | ||||||||
| Pfam | PF00929 | ||||||||
| InterPro | IPR013520 | ||||||||
| SMART | SM00479 | ||||||||
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