RHD (gene)

RHD
Identifiers
Aliases	RHD, CD240D, DIIIc, RH, RH30, RHCED, RHDVA(TT), RHDel, RHPII, RHXIII, Rh4, RhDCw, RhII, RhK562-II, RhPI, Rh blood group D antigen, HDFNRH
External IDs	OMIM: 111680 MGI: 1202882 HomoloGene: 7918 GeneCards: RHD
Gene location (Human)
Chr.	Chromosome 1 (human)
End	25,330,445 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	134,623,483 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; monocyte; ; bone marrow; ; blood; ; minor salivary gland; ; right uterine tube; ; bone marrow cells; ; stromal cell of endometrium; ; canal of the cervix; ; spleen;
	Top expressed in
	spleen; ; secondary oocyte; ; bone marrow; ; blood; ; femur; ; body of femur; ; interventricular septum; ; right ventricle; ; myocardium of ventricle; ; endocardial cushion;
	More reference expression data
	n/a
Gene ontology
Molecular function	ammonium transmembrane transporter activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	organic cation transport; ammonium transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6007
	19746
	ENSG00000187010
	ENSMUSG00000028825
	Q02161
	Q8CF94
NM_001127691; NM_001282867; NM_001282868; NM_001282869; NM_001282870;
	NM_001282871; NM_001282872; NM_016124; NM_016225
	NM_011270
NP_001121163; NP_001269796; NP_001269797; NP_001269798; NP_001269799;
	NP_001269800; NP_001269801; NP_057208
	NP_035400
	Wikidata
View/Edit Human	View/Edit Mouse

Rh blood group, D antigen also known as Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D) is a protein that in humans is encoded by the RHD gene.

The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system. RHD has sequence similarity to RHCE, RhAG, RhBG, and RhCG and these five genes constitute the Rh family. It was proposed that the erythrocyte Rh complex is a heterotrimer of RhAG, RhD, and RhCE protein subunits. RhAG is a functional ammonia transporter and is required for normal cell surface expression of RhD and RhCE. Patients who lack RhD/RhCE/RhAG on the surface of their erythrocytes have hemolytic anemia. Antibodies to the RhD protein can cause Rh disease.

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