Retinol binding protein 4

RBP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BRP, 1BRQ, 1JYD, 1JYJ, 1QAB, 1RBP, 1RLB, 2WQ9, 2WQA, 2WR6, 3BSZ, 3FMZ, 4O9S, 4PSQ
Identifiers
Aliases	RBP4, MCOPCB10, RDCCAS, retinol binding protein 4
External IDs	OMIM: 180250 MGI: 97879 HomoloGene: 4908 GeneCards: RBP4
Gene location (Human)
Chr.	Chromosome 10 (human)
End	93,601,744 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	38,113,729 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; subcutaneous adipose tissue; ; pituitary gland; ; anterior pituitary; ; abdominal fat; ; tibia; ; synovial joint; ; nucleus accumbens; ; kidney; ; pericardium;
	Top expressed in
	left lobe of liver; ; yolk sac; ; gallbladder; ; white adipose tissue; ; brown adipose tissue; ; ascending aorta; ; primitive streak; ; subcutaneous adipose tissue; ; islet of Langerhans; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	retinol transmembrane transporter activity; transporter activity; protein binding; retinoid binding; protein heterodimerization activity; retinol binding; retinal binding; small molecule binding;
Cellular component	cytosol; extracellular region; extracellular exosome; extracellular space; protein-containing complex;
Biological process	eye development; gluconeogenesis; heart trabecula formation; response to retinoic acid; glucose homeostasis; response to stimulus; cardiac muscle tissue development; lung development; vagina development; urinary bladder development; retinol metabolic process; embryonic organ morphogenesis; embryonic skeletal system development; retinoid metabolic process; female genitalia morphogenesis; uterus development; heart development; maintenance of gastrointestinal epithelium; retinol transport; embryonic retina morphogenesis in camera-type eye; response to ethanol; negative regulation of cardiac muscle cell proliferation; visual perception; positive regulation of insulin secretion; transport;
	Sources:Amigo / QuickGO
Orthologs
	5950
	19662
	ENSG00000138207
	ENSMUSG00000024990
	P02753
	Q00724
	NM_006744; NM_001323517; NM_001323518
	NM_001159487; NM_011255
	NP_001310446; NP_001310447; NP_006735
	NP_001152959; NP_035385
	Wikidata
View/Edit Human	View/Edit Mouse

Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). RBP4 has a molecular weight of approximately 21 kDa and is encoded by the RBP4 gene in humans. It is mainly, though not exclusively, synthesized in the liver and circulates in the bloodstream as a hepatokine bound to retinol in a complex with transthyretin. RBP4 has been a drug target for ophthalmology research due to its role in vision. RBP4 may also be involved in metabolic diseases as suggested by recent studies.

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