Retinoid X receptor alpha

RXRA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BY4, 1DSZ, 1FBY, 1FM6, 1FM9, 1G1U, 1G5Y, 1K74, 1LBD, 1MV9, 1MVC, 1MZN, 1R0N, 1RDT, 1RXR, 1XLS, 1XV9, 1XVP, 1YNW, 2ACL, 2NLL, 2P1T, 2P1U, 2P1V, 2ZXZ, 2ZY0, 3DZU, 3DZY, 3E00, 3E94, 3FAL, 3FC6, 3FUG, 3H0A, 3KWY, 3NSP, 3NSQ, 3OAP, 3OZJ, 3PCU, 3R29, 3R2A, 3R5M, 3UVV, 4CN2, 4CN3, 4CN5, 4CN7, 4J5W, 4J5X, 4K4J, 4K6I, 4M8E, 4M8H, 4N5G, 4N8R, 4NQA, 4OC7, 4POH, 4POJ, 4PP3, 4PP5, 4RFW, 4RMC, 4RMD, 4RME, 4ZO1, 5EC9, 4ZSH
Identifiers
Aliases	RXRA, NR2B1, Retinoid X receptor alpha, RXR-alpha, RXRalpha
External IDs	OMIM: 180245 MGI: 98214 HomoloGene: 2220 GeneCards: RXRA
Gene location (Human)
Chr.	Chromosome 9 (human)
End	134,440,585 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	27,652,969 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; gastrocnemius muscle; ; right lobe of liver; ; vastus lateralis muscle; ; blood; ; spongy bone; ; olfactory bulb; ; hair follicle; ; lower lobe of lung; ; triceps brachii muscle;
	Top expressed in
	lip; ; left lobe of liver; ; medullary collecting duct; ; ankle; ; molar; ; lacrimal gland; ; triceps brachii muscle; ; esophagus; ; knee joint; ; vastus lateralis muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; vitamin D response element binding; transcription coactivator activity; transcription factor binding; retinoic acid-responsive element binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; protein heterodimerization activity; enzyme binding; chromatin DNA binding; vitamin D receptor binding; retinoic acid binding; double-stranded DNA binding; zinc ion binding; nuclear receptor binding; peptide binding; DNA binding domain binding; LBD domain binding; DNA-binding transcription factor activity, RNA polymerase II-specific; signaling receptor activity;
Cellular component	receptor complex; nucleoplasm; RNA polymerase II transcription regulator complex; nucleus; protein-containing complex;
Biological process	steroid hormone mediated signaling pathway; regulation of branching involved in prostate gland morphogenesis; regulation of transcription, DNA-templated; placenta development; peroxisome proliferator activated receptor signaling pathway; regulation of transcription by RNA polymerase II; cholesterol metabolic process; in utero embryonic development; negative regulation of transcription by RNA polymerase II; cardiac muscle cell proliferation; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; transcription, DNA-templated; positive regulation of transcription, DNA-templated; ventricular cardiac muscle tissue morphogenesis; heart development; retinoic acid receptor signaling pathway; maternal placenta development; modulation by virus of host process; vitamin metabolic process; bile acid and bile salt transport; ventricular cardiac muscle cell differentiation; camera-type eye development; viral process; protein homotetramerization; transcription initiation from RNA polymerase II promoter; embryo implantation; positive regulation of translational initiation by iron; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; response to retinoic acid; regulation of lipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6256
	20181
	ENSG00000186350
	ENSMUSG00000015846
	P19793
	P28700
	NM_002957; NM_001291920; NM_001291921
	NM_001290481; NM_001290482; NM_011305
	NP_001278849; NP_001278850; NP_002948
	NP_001277410; NP_001277411; NP_035435
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene.

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