Resiniferatoxin
Resiniferatoxin (RTX) is a naturally occurring chemical found in resin spurge (Euphorbia resinifera), a cactus-like plant commonly found in Morocco, and in Euphorbia poissonii found in northern Nigeria. It is a potent functional analog of capsaicin, the active ingredient in chili peppers.
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IUPAC name
[(1R,2R,6R,10S,11R,13R,15R,17R)-13-Benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-(prop-1-en-2-yl)-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate | |
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MeSH | resiniferatoxin |
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CompTox Dashboard (EPA) |
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Properties | |
C37H40O9 | |
Molar mass | 628.718 g·mol−1 |
Density | 1.35 ± 0.1 g/cm3 |
insoluble in water and hexane, soluble in ethyl acetate, ethanol, methanol, acetone, chloroform, and dichloromethane. | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Resiniferatoxin | |
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Heat | Above peak (highly toxic from pungency as defined by TRPV1 activation) |
Scoville scale | 16,000,000,000 SHU |
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