Replication protein A

Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. In vitro, RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. RPA is required in replication, recombination and repair processes such as nucleotide excision repair and homologous recombination.  It also plays roles in responding to damaged DNA.

Replication protein A
(heterotrimer)
This is an image of human Replication protein A. From PDB: 1L1O​ Proteopedia protein A Replication protein A
Functiondamaged DNA binding, single-stranded DNA binding
Subunit nameGeneChromosomal locus
Replication protein A1RPA1Chr. 17 p13.3
Replication protein A2RPA2Chr. 1 p35.3
Replication protein A3RPA3Chr. 7 p21.3
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