RAS p21 protein activator 1

RASA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WER, 1WQ1, 2GQI, 2J05, 2J06, 2M51, 4FSS, 2GSB
Identifiers
Aliases	RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP, RAS p21 protein activator 1, p120, CMAVM1
External IDs	OMIM: 139150 MGI: 97860 HomoloGene: 2168 GeneCards: RASA1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	87,391,931 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	85,437,249 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; placenta; ; Brodmann area 23; ; middle temporal gyrus; ; retinal pigment epithelium; ; tibia; ; Region I of hippocampus proper; ; Brodmann area 46; ; parietal pleura; ; corpus epididymis;
	Top expressed in
	ganglionic eminence; ; medial ganglionic eminence; ; dermis; ; thymus; ; olfactory bulb; ; left lung lobe; ; atrium; ; atrioventricular valve; ; abdominal wall; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	potassium channel inhibitor activity; protein binding; GTPase binding; signaling receptor binding; GTPase activator activity; phosphotyrosine residue binding; GTPase activity;
Cellular component	cytoplasm; cytosol; intrinsic component of the cytoplasmic side of the plasma membrane; ruffle; plasma membrane;
Biological process	negative regulation of neuron apoptotic process; negative regulation of cell adhesion; intracellular signal transduction; blood vessel morphogenesis; ephrin receptor signaling pathway; regulation of GTPase activity; mitotic cytokinesis; MAPK cascade; negative regulation of Ras protein signal transduction; negative regulation of cell-matrix adhesion; vasculogenesis; regulation of actin filament polymerization; positive regulation of GTPase activity; regulation of RNA metabolic process; regulation of cell shape; signal transduction; negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5921
	218397
	ENSG00000145715
	ENSMUSG00000021549
	P20936
	E9PYG6
	NM_002890; NM_022650
	NM_145452
	NP_002881; NP_072179
	NP_663427
	Wikidata
View/Edit Human	View/Edit Mouse

RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:

Inactivation of Ras from its active GTP-bound form to its inactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain
Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

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