Raphe nuclei
The raphe nuclei (Greek: ῥαφή, "seam") are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein-inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin. The anxiolytic drug Buspirone acts as partial agonist against these receptors. Selective serotonin reuptake inhibitor (SSRI) antidepressants are believed to act in these nuclei, as well as at their targets.
| Raphe nuclei | |
|---|---|
Section of the medulla oblongata at about the middle of the olive. (Raphe nuclei not labeled, but 'raphe' labeled at left.) | |
Horizontal cross section of the brainstem at the lower pons. The raphe nucleus is labeled #18 in the middle. | |
| Details | |
| Identifiers | |
| Latin | nuclei raphe |
| MeSH | D011903 |
| NeuroLex ID | nlx_anat_20090205 |
| TA98 | A14.1.04.257 A14.1.04.318 A14.1.05.402 A14.1.05.601 A14.1.06.401 |
| TA2 | 6035, 5955 |
| FMA | 84017 |
| Anatomical terms of neuroanatomy | |
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