Ran (protein)

RAN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I2M, 1IBR, 1K5D, 1K5G, 1QBK, 1RRP, 2MMC, 2MMG, 3CH5, 3EA5, 3GJ0, 3GJ3, 3GJ4, 3GJ5, 3GJ6, 3GJ7, 3GJ8, 3GJX, 3NBY, 3NBZ, 3NC0, 3NC1, 3ZJY, 4C0Q, 4GMX, 4GPT, 4HAT, 4HAU, 4HAV, 4HAW, 4HAX, 4HAY, 4HAZ, 4HB0, 4HB2, 4HB3, 4HB4, 4OL0, 4WVF, 5CIQ, 5CIT, 5CIW, 5CJ2, 5CLL, 5CLQ, 5DH9, 5DHA, 5DHF, 5DI9, 5DIF, 3A6P, 1A2K, 5DIS, 5BXQ, 5DLQ, 5FYQ, 2N1B, 5JLJ
Identifiers
Aliases	RAN, ARA24, Gsp1, TC4, Ran, member RAS oncogene family
External IDs	OMIM: 601179 MGI: 1333112 HomoloGene: 68143 GeneCards: RAN
Gene location (Human)
Chr.	Chromosome 12 (human)
End	130,877,678 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	129,101,387 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; stromal cell of endometrium; ; right adrenal gland; ; left adrenal gland; ; rectum; ; anterior pituitary; ; upper lobe of left lung; ; body of stomach; ; left coronary artery; ; prefrontal cortex;
	Top expressed in
	otic placode; ; yolk sac; ; lens; ; habenula; ; neural tube; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; supraoptic nucleus; ; ventromedial nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; transcription coactivator activity; pre-miRNA binding; chromatin binding; protein binding; androgen receptor binding; GTPase activity; GTP binding; RNA binding; cadherin binding; magnesium ion binding; structural constituent of nuclear pore; GDP binding; protein heterodimerization activity; nuclear export signal receptor activity; metal ion binding; protein domain specific binding; protein-containing complex binding; dynein intermediate chain binding; importin-alpha family protein binding;
Cellular component	recycling endosome; cytosol; Flemming body; melanosome; nucleoplasm; midbody; RNA nuclear export complex; nucleolus; centriole; chromatin; extracellular exosome; membrane; cytoplasm; nucleus; extracellular matrix; nuclear pore; host cell; nuclear envelope; protein-containing complex; male germ cell nucleus; manchette; sperm flagellum;
Biological process	ribosomal small subunit export from nucleus; intracellular transport of virus; androgen receptor signaling pathway; protein localization to nucleolus; mitotic spindle organization; DNA metabolic process; pre-miRNA export from nucleus; cell division; positive regulation of transcription, DNA-templated; nucleocytoplasmic transport; protein export from nucleus; protein transport; ribosomal large subunit export from nucleus; cell cycle; positive regulation of protein binding; viral process; tRNA export from nucleus; mitotic cell cycle; protein import into nucleus; miRNA metabolic process; regulation of cholesterol biosynthetic process; regulation of gene silencing by miRNA; transport; mitotic sister chromatid segregation; GTP metabolic process; snRNA import into nucleus; positive regulation of protein import into nucleus; spermatid development; response to organic cyclic compound; hippocampus development; actin cytoskeleton organization; regulation of protein binding; cellular response to mineralocorticoid stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5901
	19384
	ENSG00000132341
	ENSMUSG00000029430
	P62826
	P62827
	NM_006325; NM_001300796; NM_001300797
	NM_009391
	NP_001287725; NP_001287726; NP_006316
	NP_033417
	Wikidata
View/Edit Human	View/Edit Mouse

Ran (RAs-related Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

Ran is a small G protein that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein has also been implicated in the control of DNA synthesis and cell cycle progression, as mutations in Ran have been found to disrupt DNA synthesis.

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