R gene

Resistance genes (R-Genes) are genes in plant genomes that convey plant disease resistance against pathogens by producing R proteins. The main class of R-genes consist of a nucleotide binding domain (NB) and a leucine rich repeat (LRR) domain(s) and are often referred to as (NB-LRR) R-genes or NLRs. Generally, the NB domain binds either ATP/ADP or GTP/GDP. The LRR domain is often involved in protein-protein interactions as well as ligand binding. NB-LRR R-genes can be further subdivided into toll interleukin 1 receptor (TIR-NB-LRR) and coiled-coil (CC-NB-LRR).

Leucine-rich repeat receptor-like protein kinase
Identifiers
SymbolLRRK
Membranome737
Leucine-rich repeat receptor-like protein
Identifiers
SymbolLRRP
Membranome605
TIR-NBS-LRR disease resistance proteins
Identifiers
SymbolTIR-NBS-LRR
Membranome1343
TIR domain plant proteins
Identifiers
SymbolTIRP
Membranome1344

Resistance can be conveyed through a number of mechanisms including:

Once the R protein has detected the presence of a pathogen, the plant can mount a defence against the pathogen. Because R genes confer resistance against specific pathogens, it is possible to transfer an R gene from one plant to another and make a plant resistant to a particular pathogen.

Many plant resistance proteins are single-pass transmembrane proteins that belong to receptor kinases and Toll-like receptors. R genes are of large interest in crop breeding, providing a large part of the immunity required by agricultural pathosystems.

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