RPTOR

RPTOR
Identifiers
Aliases	RPTOR, KOG1, Mip1, regulatory associated protein of MTOR complex 1
External IDs	OMIM: 607130 MGI: 1921620 HomoloGene: 80210 GeneCards: RPTOR
Gene location (Human)
Chr.	Chromosome 17 (human)
End	80,966,371 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	119,790,402 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; superficial temporal artery; ; gastrocnemius muscle; ; stromal cell of endometrium; ; popliteal artery; ; bone marrow cells; ; prefrontal cortex; ; right coronary artery; ; cingulate gyrus; ; left uterine tube;
	Top expressed in
	spermatid; ; superior frontal gyrus; ; cerebellar cortex; ; otolith organ; ; utricle; ; hand; ; renal corpuscle; ; skeletal muscle tissue; ; medullary collecting duct; ; knee joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	14-3-3 protein binding; protein-containing complex binding; TFIIIC-class transcription factor complex binding; protein binding; protein kinase binding; protein-macromolecule adaptor activity; protein kinase activator activity; protein serine/threonine kinase inhibitor activity;
Cellular component	lysosomal membrane; cytoplasm; TORC1 complex; neuronal cell body; dendrite; nucleoplasm; cytosol; cytoplasmic stress granule; lysosome;
Biological process	positive regulation of protein serine/threonine kinase activity; positive regulation of endothelial cell proliferation; regulation of phosphorylation; positive regulation of TOR signaling; cellular response to nutrient levels; TOR signaling; cellular response to amino acid stimulus; regulation of cell size; positive regulation of transcription by RNA polymerase III; regulation of cellular response to heat; activation of protein kinase activity; cellular response to starvation; regulation of autophagy; positive regulation of peptidyl-threonine phosphorylation; positive regulation of cell growth; positive regulation of peptidyl-serine phosphorylation; TORC1 signaling; negative regulation of protein serine/threonine kinase activity; positive regulation of G1/S transition of mitotic cell cycle; regulation of macroautophagy; cellular response to leucine; regulation of cell growth; viral process;
	Sources:Amigo / QuickGO
Orthologs
	57521
	74370
	ENSG00000141564
	ENSMUSG00000025583
	Q8N122
	Q8K4Q0
	NM_020761; NM_001163034
	NM_028898; NM_001306081
	NP_001156506; NP_065812
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTOR gene. Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.

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