RNA-binding protein FUS

FUS
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2LA6, 2LCW, 4FDD, 4FQ3
Identifiers
Aliases	FUS, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, FUS RNA binding protein, altFUS
External IDs	OMIM: 137070 GeneCards: FUS
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,191,605 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right uterine tube; ; right lobe of thyroid gland; ; anterior pituitary; ; left lobe of thyroid gland; ; left uterine tube; ; canal of the cervix; ; tibial nerve; ; gastric mucosa; ; skin of abdomen;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; metal ion binding; retinoid X receptor binding; thyroid hormone receptor binding; myosin V binding; protein binding; identical protein binding; nucleic acid binding; ionotropic glutamate receptor binding; estrogen receptor binding; RNA binding; chromatin binding;
Cellular component	cytoplasm; polysome; perikaryon; dendritic spine; nucleoplasm; neuronal cell body; dendrite; dendritic spine head; perinuclear region of cytoplasm; nucleus;
Biological process	cellular response to calcium ion; mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; RNA splicing; regulation of RNA splicing; protein homooligomerization; positive regulation of nucleic acid-templated transcription; positive regulation of double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologs
	2521
	n/a
	ENSG00000089280
	n/a
	P35637
	n/a
	NM_001010850; NM_001170634; NM_001170937; NM_004960
	n/a
	NP_001164105; NP_001164408; NP_004951
	n/a
	Wikidata
View/Edit Human

RNA-binding protein FUS/TLS (FUsed in Sarcoma/Translocated in LipoSarcoma), also known as heterogeneous nuclear ribonucleoprotein P2 is a protein that in humans is encoded by the FUS gene.

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