RIPK3

RIPK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4M66, 4M69
Identifiers
Aliases	RIPK3, RIP3, receptor interacting serine/threonine kinase 3
External IDs	OMIM: 605817 MGI: 2154952 HomoloGene: 31410 GeneCards: RIPK3
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,340,022 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,026,322 bp
RNA expression pattern
	Top expressed in
	blood; ; duodenum; ; spleen; ; rectum; ; appendix; ; monocyte; ; right lobe of thyroid gland; ; lymph node; ; left lobe of thyroid gland; ; gallbladder;
	Top expressed in
	yolk sac; ; thymus; ; Paneth cell; ; internal carotid artery; ; dermis; ; external carotid artery; ; jejunum; ; duodenum; ; ileum; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; transcription coactivator activity; kinase activity; protein serine/threonine kinase activity; NF-kappaB-inducing kinase activity; protein binding; identical protein binding; ATP binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; intracellular anatomical structure; mitochondrion;
Biological process	regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; amyloid fibril formation; T cell differentiation in thymus; protein heterooligomerization; phosphorylation; thymus development; regulation of interferon-gamma production; positive regulation of oxidoreductase activity; regulation of adaptive immune response; spleen development; regulation of reactive oxygen species metabolic process; regulation of activation-induced cell death of T cells; T cell homeostasis; positive regulation of phosphatase activity; positive regulation of necroptotic process; protein phosphorylation; regulation of activated T cell proliferation; positive regulation of reactive oxygen species metabolic process; NIK/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; apoptotic signaling pathway; protein autophosphorylation; positive regulation of ligase activity; necroptosis; regulation of T cell mediated cytotoxicity; I-kappaB kinase/NF-kappaB signaling; lymph node development; protein homooligomerization; activation of protein kinase activity; positive regulation of intrinsic apoptotic signaling pathway; signal transduction; programmed cell death; positive regulation of necrotic cell death; positive regulation of nucleic acid-templated transcription; cellular response to hydrogen peroxide; programmed necrotic cell death;
	Sources:Amigo / QuickGO
Orthologs
	11035
	56532
	ENSG00000129465; ENSG00000285379
	ENSMUSG00000022221
	Q9Y572
	Q9QZL0
	NM_006871
	NM_001164107; NM_001164108; NM_019955
	NP_006862
	NP_001157579; NP_001157580; NP_064339
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that is encoded by the RIPK3 gene in humans.

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce necroptosis by interaction with RIPK1 and MLKL in a protein complex termed the necrosome. Interactions between RIPK1 and RIPK3 also form a necrosome, which triggers apoptosis.

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