RIPK2

RIPK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C8B, 2N7Z, 5AR3, 5AR2, 5AR7, 5AR8, 5AR5, 5AR4, 2N83, 5J7B, 5J79
Identifiers
Aliases	RIPK2, CARD3, CARDIAK, CCK, GIG30, RICK, RIP2, receptor interacting serine/threonine kinase 2
External IDs	OMIM: 603455 MGI: 1891456 HomoloGene: 37856 GeneCards: RIPK2
EC number	2.7.10.2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	89,791,064 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	16,163,647 bp
RNA expression pattern
	Top expressed in
	monocyte; ; vena cava; ; bone marrow; ; stromal cell of endometrium; ; gallbladder; ; oocyte; ; smooth muscle tissue; ; islet of Langerhans; ; blood; ; pericardium;
	Top expressed in
	esophagus; ; secondary oocyte; ; lens; ; lip; ; submandibular gland; ; blood; ; right ventricle; ; thymus; ; yolk sac; ; saccule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	LIM domain binding; kinase activity; CARD domain binding; signaling receptor binding; ATP binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; transferase activity; protein homodimerization activity; protein binding; nucleotide binding; signal transducer activity; protein serine/threonine kinase activity; identical protein binding; caspase binding; JUN kinase kinase kinase activity;
Cellular component	cytoplasm; cytoskeleton; vesicle; cytosol; protein-containing complex;
Biological process	response to interleukin-1; positive regulation of cytokine-mediated signaling pathway; response to exogenous dsRNA; positive regulation of JNK cascade; positive regulation of xenophagy; cellular response to muramyl dipeptide; protein phosphorylation; positive regulation of ERK1 and ERK2 cascade; cellular response to peptidoglycan; positive regulation of stress-activated MAPK cascade; defense response to Gram-positive bacterium; apoptotic process; regulation of apoptotic process; positive regulation of immature T cell proliferation; positive regulation of interleukin-12 production; positive regulation of interferon-alpha production; positive regulation of peptidyl-serine phosphorylation; JNK cascade; response to interleukin-12; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of T-helper 1 type immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-tyrosine phosphorylation; inflammatory response; I-kappaB kinase/NF-kappaB signaling; nucleotide-binding oligomerization domain containing 1 signaling pathway; positive regulation of interferon-beta production; phosphorylation; immune system process; positive regulation of T-helper 1 cell differentiation; negative regulation of apoptotic process; cellular response to lipoteichoic acid; positive regulation of interleukin-2 production; positive regulation of chemokine production; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of protein ubiquitination; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon-gamma production; T cell proliferation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; peptidyl-tyrosine phosphorylation; cellular response to lipopolysaccharide; T cell receptor signaling pathway; response to interleukin-18; signal transduction; positive regulation of transcription by RNA polymerase II; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; innate immune response; MAPK cascade; adaptive immune response; positive regulation of protein binding; positive regulation of NF-kappaB transcription factor activity; activation of cysteine-type endopeptidase activity; positive regulation of cell death; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8767
	192656
	ENSG00000104312
	ENSMUSG00000041135
	O43353
	P58801
	NM_003821; NM_001375360
	NM_138952; NM_001329751
	NP_003812; NP_001362289
	NP_001316680; NP_620402
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.

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