RIPK1

RIPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ITH, 4ITI, 4ITJ, 4NEU, 5HX6
Identifiers
Aliases	RIPK1, RIP, RIP1, RIP-1, receptor interacting serine/threonine kinase 1, IMD57, AIEFL
External IDs	OMIM: 603453 MGI: 108212 HomoloGene: 2820 GeneCards: RIPK1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	3,115,187 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	34,221,130 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right lobe of liver; ; stromal cell of endometrium; ; gastric mucosa; ; Achilles tendon; ; right coronary artery; ; skin of abdomen; ; transverse colon; ; rectum; ; subcutaneous adipose tissue;
	Top expressed in
	renal corpuscle; ; Paneth cell; ; left lobe of liver; ; epithelium of stomach; ; jejunum; ; conjunctival fornix; ; medullary collecting duct; ; calvaria; ; left lung lobe; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; death domain binding; kinase activity; protein serine/threonine kinase activity; protein binding; identical protein binding; ATP binding; ubiquitin protein ligase binding; signal transducer activity; protein-containing complex binding; death receptor binding; JUN kinase kinase kinase activity;
Cellular component	membrane; receptor complex; plasma membrane; mitochondrion; death-inducing signaling complex; membrane raft; cytoplasm; cytosol; endosome membrane; ripoptosome; protein-containing complex;
Biological process	T cell apoptotic process; positive regulation of protein phosphorylation; amyloid fibril formation; positive regulation of cell death; phosphorylation; regulation of ATP:ADP antiporter activity; peptidyl-serine autophosphorylation; regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of macrophage differentiation; cellular response to tumor necrosis factor; cellular response to growth factor stimulus; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of programmed cell death; tumor necrosis factor-mediated signaling pathway; positive regulation of JNK cascade; regulation of reactive oxygen species metabolic process; negative regulation of I-kappaB kinase/NF-kappaB signaling; TRIF-dependent toll-like receptor signaling pathway; response to tumor necrosis factor; positive regulation of necroptotic process; protein phosphorylation; positive regulation of reactive oxygen species metabolic process; death-inducing signaling complex assembly; positive regulation of NF-kappaB transcription factor activity; necroptotic signaling pathway; positive regulation of interleukin-8 production; positive regulation of tumor necrosis factor production; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of extrinsic apoptotic signaling pathway; protein autophosphorylation; regulation of extrinsic apoptotic signaling pathway via death domain receptors; necroptosis; positive regulation of phosphorylation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; I-kappaB kinase/NF-kappaB signaling; activation of cysteine-type endopeptidase activity involved in apoptotic process; protein homooligomerization; positive regulation of transcription by RNA polymerase II; ripoptosome assembly; signal transduction; positive regulation of MAPK cascade; positive regulation of hydrogen peroxide-induced cell death; apoptotic signaling pathway; apoptotic process; programmed cell death; extrinsic apoptotic signaling pathway; positive regulation of necrotic cell death; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; protein deubiquitination; ripoptosome assembly involved in necroptotic process; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; viral process; protein heterooligomerization; MAPK cascade; negative regulation of cardiac muscle cell proliferation; cellular response to hydrogen peroxide; programmed necrotic cell death; positive regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of production of miRNAs involved in gene silencing by miRNA; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	8737
	19766
	ENSG00000137275
	ENSMUSG00000021408
	Q13546
	Q60855
NM_003804; NM_001317061; NM_001354930; NM_001354931; NM_001354932;
	NM_001354933; NM_001354934
	NM_009068; NM_001359997
NP_001303990; NP_003795; NP_001341859; NP_001341860; NP_001341861;
	NP_001341862; NP_001341863
	NP_033094; NP_001346926
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions in a variety of cellular pathways related to both cell survival and death. In terms of cell death, RIPK1 plays a role in apoptosis and necroptosis. Some of the cell survival pathways RIPK1 participates in include NF-κB, Akt, and JNK.

RIPK1 is an enzyme that in humans is encoded by the RIPK1 gene, which is located on chromosome 6. This protein belongs to the Receptor Interacting Protein (RIP) kinases family, which consists of 7 members, RIPK1 being the first member of the family.

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