CCL5

CCL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Identifiers
Aliases	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
External IDs	OMIM: 187011 MGI: 98262 HomoloGene: 2244 GeneCards: CCL5
Gene location (Human)
Chr.	Chromosome 17 (human)
End	35,880,793 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,421,344 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; lymph node; ; spleen; ; gallbladder; ; duodenum; ; appendix; ; bone marrow; ; bone marrow cells; ; rectum;
	Top expressed in
	spleen; ; superior surface of tongue; ; thymus; ; blood; ; jejunum; ; duodenum; ; subcutaneous adipose tissue; ; Paneth cell; ; right lung; ; right lung lobe;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	CCR5 chemokine receptor binding; receptor signaling protein tyrosine kinase activator activity; chemokine activity; protein self-association; CCR4 chemokine receptor binding; phosphatidylinositol phospholipase C activity; protein kinase activity; cytokine activity; CCR1 chemokine receptor binding; phospholipase activator activity; chemokine receptor binding; protein homodimerization activity; chemokine receptor antagonist activity; protein binding; chemoattractant activity; identical protein binding; CCR chemokine receptor binding;
Cellular component	cytoplasm; extracellular region; extracellular space;
Biological process	leukocyte cell-cell adhesion; positive regulation of cell-cell adhesion mediated by integrin; regulation of T cell activation; positive regulation of smooth muscle cell migration; activation of phospholipase D activity; negative regulation of viral genome replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of innate immune response; cellular response to interferon-gamma; positive regulation of macrophage chemotaxis; calcium ion transport; exocytosis; positive regulation of calcium ion transport; response to cytokine; regulation of insulin secretion; chemokine-mediated signaling pathway; positive regulation of cellular biosynthetic process; response to virus; positive regulation of monocyte chemotaxis; cellular response to fibroblast growth factor stimulus; neutrophil chemotaxis; response to tumor necrosis factor; negative regulation of T cell apoptotic process; positive regulation of GTPase activity; negative regulation of macrophage apoptotic process; positive regulation of T cell proliferation; positive regulation of phosphorylation; inflammatory response; positive regulation of translational initiation; response to toxic substance; positive regulation of epithelial cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; cellular response to organic cyclic compound; cellular calcium ion homeostasis; protein tetramerization; chemotaxis; positive regulation of homotypic cell-cell adhesion; cellular response to interleukin-1; immune response; positive regulation of viral genome replication; positive regulation of receptor signaling pathway via JAK-STAT; lipopolysaccharide-mediated signaling pathway; positive regulation of T cell migration; regulation of chronic inflammatory response; positive regulation of smooth muscle cell proliferation; neutrophil activation; protein kinase B signaling; positive regulation of cell migration; positive regulation of natural killer cell chemotaxis; cell-cell signaling; eosinophil chemotaxis; dendritic cell chemotaxis; MAPK cascade; macrophage chemotaxis; positive regulation of T cell chemotaxis; regulation of neuron death; positive regulation of phosphatidylinositol 3-kinase signaling; negative regulation of G protein-coupled receptor signaling pathway; positive regulation of T cell apoptotic process; positive regulation of cell adhesion; negative regulation of chemokine-mediated signaling pathway; monocyte chemotaxis; positive chemotaxis; positive regulation of protein tyrosine kinase activity; cellular response to tumor necrosis factor; positive regulation of activation of Janus kinase activity; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; lymphocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6352
	20304
	ENSG00000271503; ENSG00000274233
	ENSMUSG00000035042
	P13501
	P30882
	NM_002985; NM_001278736
	NM_013653
	NP_001265665; NP_002976
	NP_038681
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. The gene has been discovered in 1990 by in situ hybridisation and it is localised on 17q11.2-q12 chromosome. It is also known as RANTES (regulated on activation, normal T cell expressed and secreted). RANTES was first described by Dr. Tom Schall who named the protein, the original source of the name Rantes was from the Argentine movie Man Facing Southeast about an alien who shows up in a mental ward who was named Rantés, the rather clunky acronym was only made to fit the name.

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