Quinazoline

Quinazoline
Names
	Preferred IUPAC name Quinazoline
	Other names 1,3-diazanaphthalene benzopyrimidine phenmiazine benzo-1,3-diazine
Identifiers
CAS Number	253-82-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:36621 ;
ChEMBL	ChEMBL301359 ;
ChemSpider	8855 ;
ECHA InfoCard	100.005.424
EC Number	205-965-3;
PubChem CID	9210;
UNII	UB9QUR18NL ;
CompTox Dashboard (EPA)	DTXSID7075214 ;
	InChI InChI=1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H Key: JWVCLYRUEFBMGU-UHFFFAOYSA-N ; InChI=1/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H Key: JWVCLYRUEFBMGU-UHFFFAOYAV;
	SMILES c1ccc2c(c1)cncn2;
Properties
Chemical formula	C8H6N2
Molar mass	130.150 g·mol−1
Appearance	light yellow crystals
Density	1.351 g/cm3, solid
Melting point	48 °C (118 °F; 321 K)
Boiling point	243 °C (469 °F; 516 K)
Solubility in water	Soluble
Acidity (pKa)	3.51
Structure
Dipole moment	2.2 D
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Irritant
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Flash point	106 °C (223 °F; 379 K)
Safety data sheet (SDS)	External MSDS
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Quinazoline is an organic compound with the formula C₈H₆N₂. It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid that is soluble in water. Also known as 1,3-diazanaphthalene, quinazoline received its name from being an aza derivative of quinoline. Though the parent quinazoline molecule is rarely mentioned by itself in technical literature, substituted derivatives have been synthesized for medicinal purposes such as antimalarial and anticancer agents. Quinazoline is a planar molecule. It is isomeric with the other diazanaphthalenes of the benzodiazine subgroup: cinnoline, quinoxaline, and phthalazine. Over 200 biologically active quinazoline and quinoline alkaloids are identified.

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